Diagnostic Accuracy of the Risk of Ovarian Malignancy Algorithm in Clinical Practice at a Single Hospital in Korea
| العنوان: | Diagnostic Accuracy of the Risk of Ovarian Malignancy Algorithm in Clinical Practice at a Single Hospital in Korea |
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| المؤلفون: | Min Jeong Kim, Hae-il Park, Hae Nam Lee, Jae Eun Shin, Dae Woo Lee |
| المصدر: | Annals of Laboratory Medicine |
| بيانات النشر: | Annals of Laboratory Medicine, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Borderline ovarian tumor, Clinical Biochemistry, Pelvic mass, Diagnostic accuracy, Sensitivity and Specificity, Risk of Ovarian Malignancy Algorithm, 03 medical and health sciences, Ovarian tumor, WAP Four-Disulfide Core Domain Protein 2, Sensitivity, 0302 clinical medicine, Republic of Korea, Biopsy, Prevalence, Humans, Cutoff, Medicine, Ovarian malignancy, Ovarian Neoplasms, Clinical Chemistry, 030219 obstetrics & reproductive medicine, medicine.diagnostic_test, business.industry, Biochemistry (medical), Proteins, General Medicine, Middle Aged, Epithelial ovarian cancer, medicine.disease, Clinical Practice, ROC Curve, Area Under Curve, CA-125 Antigen, 030220 oncology & carcinogenesis, Specificity, Female, Original Article, Menopause, business, Ovarian cancer, Algorithm, Algorithms |
| الوصف: | Background The risk of ovarian malignancy algorithm (ROMA) is used for assessing ovarian cancer risk in women with a pelvic mass. Its diagnostic accuracy is variable. We investigated whether the clinically acceptable minimal sensitivity of >80.0% could be obtained with the suggested cutoff of 7.4%/25.3% for pre/postmenopausal women and with adjusted cutoffs set to a specificity of ≥75.0% or a sensitivity of 95.0%, in a hospital with a lower ovarian cancer (OC) prevalence than previously reported. Methods ROMA scores were calculated from measurements of human epididymis protein 4 and cancer antigen 125 in blood specimens from 443 patients with a pelvic mass. The ROMA-based risk group was compared against biopsy (N=309) or clinical follow-up with imaging (N=134) results. The ROMA sensitivity and specificity for predicting epithelial OC (EOC) and borderline ovarian tumor (BOT) were calculated for the suggested and adjusted cutoff values. Results When targeting BOT and EOC, the prevalence was 7.4% and sensitivity and specificity at the suggested cutoff were 63.6% and 90.7%, respectively. Sensitivity was 81.8% at the 4.65%/13.71% cutoff set to a specificity of 75.0%. When targeting only EOC, the prevalence was 4.1% and sensitivity and specificity at the suggested cutoff were 77.8% and 89.4%, respectively. Sensitivity was 88.9% at the 4.78%/14.35% cutoff set to a specificity of 75.0%. Conclusions The sensitivity of ROMA was lower than expected when using the suggested cutoff. When using the adjusted cutoff, its sensitivity reached 80.0%. |
| تدمد: | 2234-3814 2234-3806 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3628ef6570c1b1cd1ac195aeb2db2a4aTest https://doi.org/10.3343/alm.2019.39.3.252Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3628ef6570c1b1cd1ac195aeb2db2a4a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22343814 22343806 |
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