Outcome of in- and out-of-hospital cardiac arrest survivors with liver cirrhosis
| العنوان: | Outcome of in- and out-of-hospital cardiac arrest survivors with liver cirrhosis |
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| المؤلفون: | Pia Hubner, Thomas Horvatits, Harald Herkner, Christoph Weiser, Peter Stratil, Fritz Sterz, Dominik Jarczak, Valentin Fuhrmann, Christian Wallmüller, Karoline Rutter, Andreas Drolz, Jasmin Katrin Motaabbed, Kevin Roedl, Alexander O. Spiel, Julia Ortbauer |
| المصدر: | Annals of Intensive Care, Vol 7, Iss 1, Pp 1-9 (2017) Annals of Intensive Care |
| بيانات النشر: | SpringerOpen, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | medicine.medical_specialty, Cirrhosis, medicine.medical_treatment, Disease, Critical Care and Intensive Care Medicine, Out of hospital cardiac arrest, law.invention, 03 medical and health sciences, 0302 clinical medicine, law, Anesthesiology, Internal medicine, medicine, In patient, Intensive care unit, Cardiopulmonary resuscitation, business.industry, Research, lcsh:Medical emergencies. Critical care. Intensive care. First aid, 030208 emergency & critical care medicine, lcsh:RC86-88.9, medicine.disease, Cardiac arrest, Multiple organ failure, Surgery, Acute-on-chronic liver failure, Etiology, 030211 gastroenterology & hepatology, business |
| الوصف: | Background Organ failure increases mortality in patients with liver cirrhosis. Data about resuscitated cardiac arrest patients with liver cirrhosis are missing. This study aims to assess aetiology, survival and functional outcome in patients after successful cardiopulmonary resuscitation (CPR) with and without liver cirrhosis. Methods Analysis of prospectively collected cardiac arrest registry data of consecutively hospital-admitted patients following successful CPR was performed. Patient’s characteristics, admission diagnosis, severity of disease, course of disease, short- and long-term mortality as well as functional outcome were assessed and compared between patients with and without cirrhosis. Results Out of 1068 patients with successful CPR, 47 (4%) had liver cirrhosis. Acute-on-chronic liver failure (ACLF) was present in 33 (70%) of these patients on admission, and four patients developed ACLF during follow-up. Mortality at 1 year was more than threefold increased in patients with liver cirrhosis (OR 3.25; 95% CI 1.33–7.96). Liver cirrhosis was associated with impaired neurological outcome (OR for a favourable cerebral performance category: 0.13; 95% CI 0.04–0.36). None of the patients with Child–Turcotte–Pugh (CTP) C cirrhosis survived 28 days with good neurological outcome. Overall nine (19%) patients with cirrhosis survived 28 days with good neurological outcome. All patients with ACLF grade 3 died within 28 days. Conclusion Cardiac arrest survivors with cirrhosis have worse outcome than those without. Although one quarter of patients with liver cirrhosis survived longer than 28 days after successful CPR, patients with CTP C as well as advanced ACLF did not survive 28 days with good neurological outcome. Electronic supplementary material The online version of this article (doi:10.1186/s13613-017-0322-1) contains supplementary material, which is available to authorized users. |
| اللغة: | English |
| تدمد: | 2110-5820 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f655a551c9ce252157a2caf13d47e316Test http://link.springer.com/article/10.1186/s13613-017-0322-1Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f655a551c9ce252157a2caf13d47e316 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21105820 |
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