دورية أكاديمية
Sarcopenia Predicts Reduced Survival in Patients with Hepatocellular Carcinoma at First Diagnosis
| العنوان: | Sarcopenia Predicts Reduced Survival in Patients with Hepatocellular Carcinoma at First Diagnosis |
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| المؤلفون: | Paola Begini, Elia Gigante, Giulio Antonelli, Francesco Carbonetti, Elsa Iannicelli, Giulia Anania, Barbara Imperatrice, Adriano Maria Pellicelli, Gianfranco Delle Fave, Massimo Marignani |
| المصدر: | Annals of Hepatology, Vol 16, Iss 1, Pp 107-114 (2017) |
| بيانات النشر: | Elsevier, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Specialties of internal medicine |
| مصطلحات موضوعية: | Muscle wasting, Cirrhosis, Prognosis, Skeletal muscle index, Liver Cancer, Specialties of internal medicine, RC581-951 |
| الوصف: | Background: Sarcopenia is a complication and independent risk factor for mortality in patients with liver cirrhosis. Aim: To assess the prevalence and influence of sarcopenia on overall survival in a cohort of cirrhotic patients with hepatocellular carcinoma managed in a tertiary center. Material and Methods: Abdominal computed tomography of 92 consecutive hepatocellular carcinoma cirrhotic patients, enrolled and followed from 2004 to 2014, were retrospectively studied with a software analyzing the cross-sectional areas of muscles at third lumbar vertebra level. Data was normalized for height, skeletal muscle index (SMI) calculated and presence of Sarcopenia measured. Sarcopenia was defined by SMI ≤ 41 cm2/m2 for women and ≤ 53 cm2/m2 for men with body mass index (BMI) ≥ 25, and ≤ 43 cm2/m2 for men and women with BMI < 25, respectively. Results: Median age at diagnosis was 71.9 years (30.7-86.4) and BMI 24.7 (17.5-36.7), comparable in women 23.1, (17.5-36.7) and men 24.7 (18.4-36.7). A class of CHILD score and BCLC A prevailed (55.4% and 41.3%, respectively); metastatic disease was found in 12% of cases. Sarcopenia was present in 40.2% of cases, mostly in females (62.9%; p = 0.005). Mean overall survival was reduced in sarcopenic patients, 66 (95% CI 47 to 84) vs. 123 (95% CI 98 to 150) weeks (p = 0.001). At multivariate analysis, sarcopenia was a predictor of reduced overall survival, independent of age (p = 0.0027). Conclusions: This retrospective study shows high prevalence of sarcopenia among cirrhotic patients with hepatocellular carcinoma. Presence of sarcopenia was identified as independent predictor of reduced overall survival. As easily measurable by CT, sarcopenia should be determined for prognostic purposes in this patient population. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1665-2681 16652681 |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S1665268119303679Test; https://doaj.org/toc/1665-2681Test |
| DOI: | 10.5604/16652681.1226821 |
| الوصول الحر: | https://doaj.org/article/8ad0a70044e84d138ebe69444233a536Test |
| رقم الانضمام: | edsdoj.8ad0a70044e84d138ebe69444233a536 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16652681 |
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| DOI: | 10.5604/16652681.1226821 |