التفاصيل البيبلوغرافية
| العنوان: |
WPSS is a strong prognostic indicator for clinical outcome of allogeneic transplant for myelodysplastic syndrome in Southeast Asian patients. |
| المؤلفون: |
Ma, Liyuan, Hao, Siguo, Diong, Colin, Goh, Yeow-Tee, Gopalakrishnan, Sathish, Ho, Aloysius, Hwang, William, Koh, Liang-Piu, Koh, Mickey, Lim, Zi-Yi, Loh, Yvonne, Poon, Michelle, Tan, Lip-Kun, Tan, Patrick, Linn, Yeh-Ching |
| المصدر: |
Annals of Hematology; May2015, Vol. 94 Issue 5, p761-769, 9p |
| مصطلحات موضوعية: |
MYELODYSPLASTIC syndromes, BONE marrow diseases, SOUTHEAST Asians, ASIANS, MEDICAL care |
| مستخلص: |
To better understand the predictive factors and improve clinical outcome of allogeneic transplant for patients with myelodysplastic syndrome (MDS), we retrospectively analyzed the post-transplant outcome of 60 Southeast Asian patients with MDS. Multivariate analysis showed that WHO classification-based Prognostic Scoring System (WPSS) significantly affect overall survival (OS), progression-free survival (PFS), cumulative incidence of relapse (CIR), and cumulative incidence of non-relapse mortality (CINRM). Stratified by WPSS into very low/low, intermediate, high, and very high-risk categories, 3-year OS was 100, 61, 37, and 18 % ( p = 0.02); PFS was 100, 55, 32, and 18 % ( p = 0.014); CIR was 12, 24, 38, and 59 % ( p = 0.024); CINRM was 0, 6, 12, and 26 % ( p = 0.037), respectively. WHO classification, Revised International Prognostic Scoring System (IPSS-R), IPSS-R-defined cytogenetic risk groups, donor gender, and acute and chronic graft vs host disease (GVHD) also influenced different aspects of transplant outcome. We found that WPSS is a powerful predictor of post-transplant outcome. WPSS provides an important model not only for prognostication but also for exploration of further post-transplant measures such as immunological maneuvers or novel therapy to improve the poor outcome of high-risk patients. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
