Endothelial dysfunction after bone marrow transplantation: Increase of soluble thrombomodulin and PAI-1 in patients with multiple transplant-related complications
| العنوان: | Endothelial dysfunction after bone marrow transplantation: Increase of soluble thrombomodulin and PAI-1 in patients with multiple transplant-related complications |
|---|---|
| المؤلفون: | Wenzel Nürnberger, S Burdach, Ulrich Göbel, I. Michelmann |
| المصدر: | Annals of Hematology. 76:61-65 |
| بيانات النشر: | Springer Science and Business Media LLC, 1998. |
| سنة النشر: | 1998 |
| مصطلحات موضوعية: | Adult, medicine.medical_specialty, Adolescent, Endothelium, Thrombomodulin, Hepatic Veno-Occlusive Disease, Graft vs Host Disease, Gastroenterology, Sepsis, chemistry.chemical_compound, Internal medicine, Plasminogen Activator Inhibitor 1, medicine, Humans, Endothelial dysfunction, Child, Bone Marrow Transplantation, Hematology, business.industry, Infant, General Medicine, medicine.disease, Surgery, surgical procedures, operative, medicine.anatomical_structure, Solubility, chemistry, Child, Preschool, Plasminogen activator inhibitor-1, Endothelium, Vascular, Bone marrow, business, Complication, Biomarkers, Capillary Leak Syndrome |
| الوصف: | Multiple transplant-related complications (MTRC) represent a severe condition after bone marrow transplantation (BMT) and are supposed to reflect systemic endothelial damage. Soluble thrombomodulin (sTM) and plasminogen activator inhibitor type-1 (PAI-1) were investigated as markers of endothelial dysfunction in 35 patients after autologous or allogeneic BMT and compared with the occurrence of the typical complications sepsis, veno-occlusive disease of the liver (VOD), graft-versus-host disease (GVHD), and capillary leakage syndrome (CLS). PAI-1 was assessed by an assay of functional activity and sTM by antigenic determination. In patients who had undergone allogeneic BMT and had no transplant-related complications (TRC), PAI-1 peaked on day +14 (20 +/- 5 units/ml), and sTM doubled in comparison to the starting range, to 60-80 ng/ml between days +14 and +49. In contrast, PAI-1 and sTM were unchanged following autologous BMT. PAI-1 was increased in sepsis, CLS, and VOD to 39-49 units/ml (p0.05, compared with patients without TRC), and in GVHD to 16-47 units/ml (not significant). Soluble TM increased to 63-309 ng/ml in patients with sepsis, VOD, or CLS (p0.05, compared with patients without TRC) and to 79-224 ng/ml in GVHD (not significant). The increase of sTM and PAI-1 was also positively correlated to the number of complications, so that in patients with three complications PAI-1 was increased 2.8-fold and sTM 3.5-fold over patients with no complications at all. We conclude that endothelial dysfunction is a feature of VOD, sepsis, CLS, and to lesser extent of GVHD and is worse in patients with multiple complications. |
| تدمد: | 1432-0584 0939-5555 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3245956ead8fc65ae6a59a8e84265e22Test https://doi.org/10.1007/s002770050364Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....3245956ead8fc65ae6a59a8e84265e22 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14320584 09395555 |
|---|