Fibro-osseous pseudotumor of digits - Expanding the spectrum of clonal transient neoplasms harboring USP6 rearrangement
| العنوان: | Fibro-osseous pseudotumor of digits - Expanding the spectrum of clonal transient neoplasms harboring USP6 rearrangement |
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| المؤلفون: | Paul J. van Diest, Sarah J. Shepard, Elise M. Bekers, Uta Flucke, David Creytens, Joost van Gorp, Roberto Tirabosco |
| المصدر: | Annals of Diagnostic Pathology, 35, pp. 53-55 Annals of Diagnostic Pathology, 35, 53. W.B. Saunders Ltd Annals of Diagnostic Pathology, 35, 53-55 |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Adult, Male, Pathology, medicine.medical_specialty, Fibro-osseous pseudotumor of digits, Soft Tissue Neoplasms, Other Research Radboud Institute for Molecular Life Sciences [Radboudumc 0], Nodular fasciitis, Rare cancers Radboud Institute for Molecular Life Sciences [Radboudumc 9], Pathology and Forensic Medicine, Lesion, Diagnosis, Differential, Fingers, 03 medical and health sciences, Soft tissue tumors, 0302 clinical medicine, All institutes and research themes of the Radboud University Medical Center, Proto-Oncogene Proteins, medicine, Humans, Fasciitis, Exostosis, Aged, Gene Rearrangement, business.industry, Soft tissue, General Medicine, Aneurysmal bone cyst, Myositis ossificans, Middle Aged, medicine.disease, stomatognathic diseases, 030104 developmental biology, Giant cell, 030220 oncology & carcinogenesis, Female, USP6 rearrangement, medicine.symptom, Palm, business, Ubiquitin Thiolesterase |
| الوصف: | Fibro-osseous pseudotumors of the digits (FOPD) is a rare self-limiting lesion composed of bland looking hypercellular fibrous tissue and bone. USP6 rearrangement is a consistent genetic finding in aneurysmal bone cyst, nodular fasciitis, myositis ossificans and giant cell lesions of small bones. We report herein the occurrence of USP6 rearrangement in fibro-osseous pseudotumors of the digits using fluorescence in situ hybridization analysis (FISH). Of the five patients included, three were female and two were male. The age ranged from 33 to 72 years (mean 48 years). Lesions arose in the palm (n = 2), thenar (n = 1), middle finger (n = 1) and great toe (n = 1). All patients underwent resection. Four cases (80%) harbored USP6 rearrangements showing that fibro-osseous pseudotumors of digits belongs to the spectrum of clonal transient neoplasms including aneurysmal bone cyst, nodular fasciitis, myositis ossificans and giant cell lesion of small bones. |
| وصف الملف: | image/pdf; application/pdf |
| تدمد: | 1092-9134 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d5796c04197545aaceeb2b89aa11ae7Test https://hdl.handle.net/2066/194718Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1d5796c04197545aaceeb2b89aa11ae7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10929134 |
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