التفاصيل البيبلوغرافية
| العنوان: |
From the archives of MD Anderson Cancer Center: Plasmablastic lymphoma presenting as a kidney mass in an immunocompetent patient: Case report and literature review. |
| المؤلفون: |
Gietzen, Rachelle, Muthukumarana, Vidarshi, Bhargava, Peeyush, Vozniuk, Dmitrii, Thakral, Beenu, Medeiros, L. Jeffrey, Lyapichev, Kirill A. |
| المصدر: |
Annals of Diagnostic Pathology; Dec2023, Vol. 67, pN.PAG-N.PAG, 1p |
| مستخلص: |
Plasmablastic lymphoma (PBL) is a rare, aggressive large B-cell lymphoma with plasmablastic or immunoblastic morphology and a terminally differentiated B-cell immunophenotype. PBL often presents at extranodal sites, commonly the oral cavity of immunocompromised patients with human immunodeficiency virus (HIV) and/or Epstein-Barr virus (EBV) infection. Cases of PBL arising outside the oral cavity in previously healthy immunocompetent patients are rare. We report a 65-year-old HIV- and EBV-negative man who presented with abdominal pain, fatigue, and vomiting. Imaging studies showed a 30 × 18 cm bulky lobulated mass located within the left kidney with surrounding para-aortic lymphadenopathy. Serum and urine protein electrophoresis revealed a monoclonal gammopathy of IgA lambda type. Biopsy of the mass showed PBL. Bone marrow lumbar puncture evaluations also showed evidence of PBL. The patient was treated with chemotherapy and radiation with initial improvement; however, he died 14 months after initial diagnosis. Based on our literature review, this case of PBL is one of the few reported to present as a kidney mass in immunocompetent, HIV- and EBV-negative patient. Distinguishing PBL from plasma cell myeloma (PCM) can be challenging. Knowledge of clinical features including presence of CRAB (hypercalcemia, renal failure, anemia, bone lesions) or bone marrow infiltration by mature clonal plasma cells is helpful to establish a diagnosis of PCM. Genetic features of PCM (typical translocations or mutations) also can be helpful in distinguishing plasmablastic transformation of PCM and from PBL. The case we report also highlights the need for more studies to identify specific immunohistochemical and molecular markers to improve PBL diagnosis in immunocompetent patients. • PBL rarely involves the kidneys and are an extremely rare primary site of PBL. • The diagnosis of PBL can be challenging due to its clinical similarities with plasma cell myeloma and some types of DLBCL. • PBL is more commonly diagnosed in males (75%) and most often presents at extranodal sites. • Most cases of PBL closely associated with HIV and EBV infection. [ABSTRACT FROM AUTHOR] |
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