Subplate in a rat model of preterm hypoxia-ischemia
| العنوان: | Subplate in a rat model of preterm hypoxia-ischemia |
|---|---|
| المؤلفون: | Franziska M. Oeschger, Zoltán Molnár, Vanessa Ginet, Chika Okusa, Wei Zhi Wang, Tomohiro Matsuyama, Anna Hoerder-Suabedissen, Anita C. Truttmann |
| المصدر: | Annals of Clinical and Translational Neurology Annals of Clinical and Translational Neurology, vol. 1, no. 9, pp. 679-691 |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Pathology, medicine.medical_specialty, business.industry, General Neuroscience, Rat model, Hypoxia (medical), Hypoxia ischemia, White matter, CTGF, medicine.anatomical_structure, Subplate, Occlusion, Immunohistochemistry, Medicine, Neurology (clinical), medicine.symptom, business, Research Articles |
| الوصف: | Objective Hypoxia–ischemia (HI) in preterm infants primarily leads to injuries in the cerebral white matter. However, there is growing evidence that perinatal injury in preterms can also involve other zones including the cortical gray matter. In a neonatal rat model of HI, selective vulnerability of subplate has been suggested using BrdU birth-dating methods. In this study, we aimed to investigate the neuropathological changes of the subplate and deep layers of the cortex following cerebral HI in neonatal rats with specific cell markers. Methods P2 rats underwent permanent occlusion of the right common carotid artery followed by a period of hypoxia. P8 rats were analyzed using immunohistochemistry; subplate and deep layers cells were quantified and compared with sham-operated case. Results A large variability in the extent of the cerebral injury was apparent. For the three analyzed subplate populations (Nurr1+, Cplx3+, and Ctgf+ cells), no significant cell reduction was observed in mild and moderate cases. Only in severe cases, subplate cells were strongly affected, but these injuries were always accompanied by the cell reductions in layers VI and V. Interpretation We could therefore not confirm a specific vulnerability of subplate cells compared to other deep layers or the white matter in our model. |
| وصف الملف: | application/pdf |
| تدمد: | 2328-9503 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a066a74523e1c2a4ef2df7ceed442d5cTest https://pubmed.ncbi.nlm.nih.gov/25493282Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a066a74523e1c2a4ef2df7ceed442d5c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23289503 |
|---|