دورية أكاديمية
In‐depth peripheral CD4+ T profile correlates with myasthenic crisis
| العنوان: | In‐depth peripheral CD4+ T profile correlates with myasthenic crisis |
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| المؤلفون: | Xiao Huan, Sushan Luo, Huahua Zhong, Xueying Zheng, Jie Song, Lei Zhou, Jun Lu, Ying Wang, Yafang Xu, Jianying Xi, Zhangyu Zou, Sheng Chen, Chongbo Zhao |
| المصدر: | Annals of Clinical and Translational Neurology, Vol 8, Iss 4, Pp 749-762 (2021) |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Neurosciences. Biological psychiatry. Neuropsychiatry LCC:Neurology. Diseases of the nervous system |
| مصطلحات موضوعية: | Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429 |
| الوصف: | Abstract Objective Myasthenia gravis (MG) is an autoimmune disease caused by autoantibodies against neuromuscular junctions. Myasthenic crisis (MC) represents the most severe state of MG with high in‐hospital mortality. We aimed to identify immune signatures using in‐depth profiling in MC, and to assess the correlations between immune biomarkers with clinical severity longitudinally. Methods We studied 181 participants including 57 healthy controls, 96 patients with MG who never experienced crisis and 28 MC patients from December 2018 through June 2020. Follow‐up visits occurred prospectively from crisis to 6 months off‐mechanical ventilation. The frequencies of 20 CD4+ T subpopulations and 18 serum cytokines were associated with clinical scores using correlations and principal component analysis. Results Patients in crisis exhibited a proinflammatory CD4+T response with elevated Th1 (P = 0.026), and Th17 cells (P = 0.032); decreased T follicular helper 2 (Tfh2) cells (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2328-9503 |
| العلاقة: | https://doaj.org/toc/2328-9503Test |
| DOI: | 10.1002/acn3.51312 |
| الوصول الحر: | https://doaj.org/article/e13da6b026764a6caf043050bd084c0bTest |
| رقم الانضمام: | edsdoj.13da6b026764a6caf043050bd084c0b |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23289503 |
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| DOI: | 10.1002/acn3.51312 |