Comparative Efficacy of Statins for Prevention of Contrast-Induced Acute Kidney Injury in Patients With Chronic Kidney Disease: A Network Meta-Analysis
| العنوان: | Comparative Efficacy of Statins for Prevention of Contrast-Induced Acute Kidney Injury in Patients With Chronic Kidney Disease: A Network Meta-Analysis |
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| المؤلفون: | Zhijun Wang, Wei Mao, Jin Dai, Xiaoming Xu, Haibin Xu, Yuangang Qiu, Xinbin Zhou, Jie Chen |
| المصدر: | Angiology. 70:305-316 |
| بيانات النشر: | SAGE Publications, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, Cardiac Catheterization, Comparative Effectiveness Research, medicine.medical_specialty, Statin, medicine.drug_class, Atorvastatin, medicine.medical_treatment, Contrast Media, 030204 cardiovascular system & hematology, Cochrane Library, Kidney, urologic and male genital diseases, Drug Administration Schedule, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, medicine, Humans, Rosuvastatin, 030212 general & internal medicine, Renal Insufficiency, Chronic, Rosuvastatin Calcium, Aged, Randomized Controlled Trials as Topic, Cardiac catheterization, business.industry, Acute kidney injury, Odds ratio, Acute Kidney Injury, Middle Aged, medicine.disease, female genital diseases and pregnancy complications, Treatment Outcome, Female, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Cardiology and Cardiovascular Medicine, business, Kidney disease, medicine.drug |
| الوصف: | Contrast-induced acute kidney injury (CI-AKI) is a common complication of iodinated contrast medium administration during cardiac catheterization. Statin treatment has been shown to be associated with reduced risk of CI-AKI; however, the results are inconsistent, especially for patients with chronic kidney disease (CKD). Thus, we conducted a network meta-analysis to evaluate the effects of statins in the prevention of CI-AKI. We systematically searched several databases (including, Embase, PubMed, the Cochrane Library, and ClinicalTrials.gov ) from inception to January 31, 2018. The primary outcome was occurrence of CI-AKI in patients with CKD undergoing cardiac catheterization. Both pairwise and network meta-analysis were performed. Finally, 21 randomized controlled trials with a total of 6385 patients were included. Results showed that statin loading before contrast administration was associated with a significantly reduced risk of CI-AKI in patients with CKD undergoing cardiac catheterization (odds ratio: 0.46; P < .05). Atorvastatin and rosuvastatin administered at high dose may be the most effective treatments to reduce incidence of CI-AKI, with no difference between these 2 agents. |
| تدمد: | 1940-1574 0003-3197 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e83cea832eb93053754f9cbfde97901Test https://doi.org/10.1177/0003319718801246Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....4e83cea832eb93053754f9cbfde97901 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19401574 00033197 |
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