Periaortic Adipose Tissue Compared With Peribrachial Adipose Tissue Mass as Markers and Possible Modulators of Cardiometabolic Risk
| العنوان: | Periaortic Adipose Tissue Compared With Peribrachial Adipose Tissue Mass as Markers and Possible Modulators of Cardiometabolic Risk |
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| المؤلفون: | Elko Randrianarisoa, Kilian Rittig, Hans-Ulrich Häring, Bernd Balletshofer, Nadja Reis-Damaschk, Andreas Fritsche, Anja Hieronimus, Dorothea Siegel-Axel, Jürgen Machann, Norbert Stefan |
| المصدر: | Angiology. 69:854-860 |
| بيانات النشر: | SAGE Publications, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adipose tissue, 030209 endocrinology & metabolism, Intra-Abdominal Fat, 030204 cardiovascular system & hematology, Carotid Intima-Media Thickness, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Insulin resistance, Risk Factors, Internal medicine, medicine, Humans, Aged, Cardiometabolic risk, Univariate analysis, business.industry, Insulin sensitivity, Arteriosclerosis, Glucose Tolerance Test, Middle Aged, Atherosclerosis, medicine.disease, Fatty Liver, Endocrinology, Adipose Tissue, Intima-media thickness, Subclinical atherosclerosis, Female, Cardiology and Cardiovascular Medicine, business, Biomarkers |
| الوصف: | Increased perivascular fat mass contributes to cardiometabolic risk (CMR). High peribrachial adipose tissue (PBAT) associates with insulin resistance independently of established CMR parameters. It is unknown to what extent periaortic adipose tissue (PAAT) may have a similar impact. In 95 participants, precise quantification of total adipose tissue, PBAT, PAAT, visceral adipose tissue (VAT), and liver fat (LF) content was performed by whole-body magnetic resonance imaging. Insulin sensitivity was determined by oral glucose tolerance test and carotid intima–media thickness (cIMT) by high-resolution ultrasound. In univariate analyses, PAAT correlated with PBAT (β = .65, P < .0001). A negative correlation of PAAT (β = −.35, P = .0002) and PBAT (β = −.43, P < .0001) with insulin sensitivity was observed. While in a stepwise forward regression analysis the relationship of PAAT with insulin sensitivity was no longer significant after adjustment for VAT, LF content, and other CMR factors ( P = 0.42), PBAT still correlated with insulin sensitivity ( r2 = .35, P = .01). The association between PAAT and cIMT (β = .49, P < .0001) remained significant after adjustment for these variables ( r2 = .42, P = .0001). Although PAAT and PBAT strongly correlate, PAAT is not associated with insulin resistance, but with cIMT. Therefore, PAAT and PBAT may act differently as possible modulators of insulin resistance and subclinical atherosclerosis. |
| تدمد: | 1940-1574 0003-3197 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e3cdb7a0dfea77ef76c20eb7103b1eTest https://doi.org/10.1177/0003319718755581Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....92e3cdb7a0dfea77ef76c20eb7103b1e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19401574 00033197 |
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