التفاصيل البيبلوغرافية
| العنوان: |
Testicular function after non‐cytotoxic and immunotherapy drug treatment. |
| المؤلفون: |
Handelsman, David J., Idan, Amanda, Sleiman, Sue, Bacha, Fey, Long, Georgina V., Menzies, Alexander M., Vaishnav, Tejnei, Litkouhi, Noosha, Volckmar, Xanthie, Ledger, William, Anazodo, Antoinette |
| المصدر: |
Andrology; May2024, Vol. 12 Issue 4, p891-898, 8p |
| مصطلحات موضوعية: |
TESTIS physiology, IMMUNOTHERAPY, IMMUNE checkpoint inhibitors, FOLLICLE-stimulating hormone, CANCER treatment, CRYOPROTECTIVE agents |
| مستخلص: |
Background: The effects of novel non‐cytotoxic and immunotherapy drugs for cancer treatment on human testicular function have not been studied systematically. Objectives: The present study aimed to characterize effects of non‐cytotoxic and immunotherapy drugs in patients with cancers who had not been previously treated with gonadotoxic chemo‐ or radiotherapy. Materials and methods: This study involved 34 men, not previously treated with gonadotoxic regimens, in a mixed longitudinal (Cohort 1: 19 men about to start and approximately 1 year on non‐cytotoxic and immunotherapy treatment) and cross‐sectional (Cohort 2: 15 men already on non‐cytotoxic and immunotherapy treatment) study using data modeling to estimate within‐person time‐course changes in testicular exocrine and endocrine functions. Cohort 1 provided 45 paired semen and blood samples (34 prior to and nine during treatment) and Cohort 2 provided 45 sets of samples (15 pre‐treatment, 30 on treatment), including six men in Cohort 2 who had pre‐treatment spermatozoa cryostorage prior to the study. Men on non‐cytotoxic and immunotherapy treatment had undergone a median of 33.5 months long‐term treatment. Results: Spermatozoa output and concentration were reduced by about 50%, with corresponding increases in serum follicle‐stimulating hormone and decreases in serum inhibin B. Serum testosterone, luteinizing hormone, and sex hormone‐binding globulin were unaffected by non‐cytotoxic and immunotherapy treatment. Conclusion: Within limits of the present study of sample size and duration of on‐non‐cytotoxic and immunotherapy treatment, non‐cytotoxic and immunotherapy drugs have a modest effects on testicular exocrine function (sperm production) or its hormonal correlates (follicle‐stimulating hormone, inhibin B), with minimal impact on testicular endocrine (testosterone, luteinizing hormone) function. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
