Requirement of Smad4-mediated signaling in odontoblast differentiation and dentin matrix formation
| العنوان: | Requirement of Smad4-mediated signaling in odontoblast differentiation and dentin matrix formation |
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| المؤلفون: | Jin A Baek, Hwajung Choi, Youngjae You, Chi Young Yun, Jin Young Yang, Eui Sic Cho |
| المصدر: | Anatomy & Cell Biology |
| بيانات النشر: | Korean Association of Anatomists, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Histology, Odontoblast differentiation, Bone morphogenetic protein, 03 medical and health sciences, Cellular and Molecular Neuroscience, stomatognathic system, Dentin, medicine, Dental papilla, Odontoblasts, Chemistry, Inner enamel epithelium, Cell Biology, Anatomy, Amelogenesis, Development/Regeneration, TGF-β/BMP signaling, Cell biology, stomatognathic diseases, 030104 developmental biology, Odontoblast, medicine.anatomical_structure, Dentinogenesis, Original Article, Smad4, Developmental Biology |
| الوصف: | Dentin is the major part of tooth and formed by odontoblasts. Under the influence of the inner enamel epithelium, odontoblasts differentiate from ectomesenchymal cells of the dental papilla and secrete pre-dentin which then undergo mineralization into dentin. Transforming growth factor-beta (TGF-β)/bone morphogenetic protein (BMP) signaling is essential for dentinogenesis; however, the precise molecular mechanisms remain unclear. To understand the role of TGF-β/BMP signaling in odontoblast differentiation and dentin formation, we generated mice with conditional ablation of Smad4, a key intracellular mediator of TGF-β/BMP signaling, using Osr2 or OC-Cre mice. Here we found the molars of Osr2CreSmad4 mutant mice exhibited impaired odontoblast differentiation, and normal dentin was replaced by ectopic bone-like structure. In Osr2CreSmad4 mutant mice, cell polarity of odontoblast was lost, and the thickness of crown dentin was decreased in later stage compared to wild type. Moreover, the root dentin was also impaired and showed ectopic bone-like structure similar to Osr2CreSmad4 mutant mice. Taken together, our results suggest that Smad4-dependent TGF-β/BMP signaling plays a critical role in odontoblast differentiation and dentin formation during tooth development. |
| تدمد: | 2093-3673 2093-3665 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b2bb9d69a9ab1c79e659e00fe27483cTest https://doi.org/10.5115/acb.2016.49.3.199Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0b2bb9d69a9ab1c79e659e00fe27483c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20933673 20933665 |
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