Relationship of activin A levels with clinical presentation, extent, and severity of coronary artery disease
| العنوان: | Relationship of activin A levels with clinical presentation, extent, and severity of coronary artery disease |
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| المؤلفون: | Fethi Betbout, Faouzi Maatouk, Abdelhedi Miled, Salima Ferchichi, Nadia Bouzidi, Habib Gamra |
| المصدر: | Anatolian Journal of Cardiology |
| بيانات النشر: | Kare Publishing, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Adult, Male, medicine.medical_specialty, Population, severity, Coronary Artery Disease, 030204 cardiovascular system & hematology, Coronary Angiography, Severity of Illness Index, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Predictive Value of Tests, Risk Factors, Internal medicine, Severity of illness, medicine, Humans, Myocardial infarction, cardiovascular diseases, education, Original Investigation, education.field_of_study, Framingham Risk Score, Predictive marker, Unstable angina, business.industry, Case-control study, Activin A, Middle Aged, medicine.disease, Activins, extent, 030104 developmental biology, Case-Control Studies, Cardiology, ST Elevation Myocardial Infarction, Female, Cardiology and Cardiovascular Medicine, business, Biomarkers |
| الوصف: | Objective We aimed to evaluate the relationship of serum activin A levels with risk factors, clinical presentation, biochemical marker levels, extent, and severity of atherosclerotic coronary artery disease (CAD). Methods In total, 310 CAD patients [92 with ST-segment elevation myocardial infarction (STEMI), 111 with non-STEMI (NSTEMI), and 107 with unstable angina (UA)] and 207 healthy subjects (controls) were enrolled. Activin A levels in all participants were measured using ELISA. Angiographic measurements were performed in patients and not in the healthy subjects. Results Activin A levels were higher in all patient groups than in controls (patients vs. controls, p=0.041; NSTEMI vs. UA, p=0.744; STEMI vs. UA, p=0.172; NSTEMI vs. STEMI, p=0.104). According to the cut-off value of activin A level, patients with high and low activin A levels had a similar distribution of clinical and biochemical variables but the prevalence of severe stenosis was observed in groups with high activin A levels. Our results revealed that activin A levels did not decrease as thrombolysis in myocardial infarction (risk score increased (p=0.590). The area under the ROC curve for activin A levels in patients was 0.590±0.047 (95% CI: 0.439-0.591, p=0.193). In multiple analysis of the overall population, male gender (s=-0.260; 95% CI: -617.39 to -110.04; p=0.005) was an independent predictor of activin A levels. Conclusion This study indicated that activin A can not be a predictive marker in CAD and is not associated with extensive and severe CAD. In contrast, the increase in activin A levels in patients, especially in patients with different clinical groups of acute coronary syndromes, suggested its involvement in atherosclerosis. |
| اللغة: | English |
| تدمد: | 2149-2271 2149-2263 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d0df721b35286a112c290502d6d634cTest http://europepmc.org/articles/PMC6282897Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6d0df721b35286a112c290502d6d634c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21492271 21492263 |
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