Amyotrophic Lateral Sclerosis Survival Score (ALS-SS): A simple scoring system for early prediction of patient survival
| العنوان: | Amyotrophic Lateral Sclerosis Survival Score (ALS-SS): A simple scoring system for early prediction of patient survival |
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| المؤلفون: | Valeria A. Sansone, Christian Lunetta, Mario Melazzini, Andrea Lizio, Eleonora Maestri |
| المصدر: | Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 17:93-100 |
| بيانات النشر: | Informa UK Limited, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, 030204 cardiovascular system & hematology, Risk Assessment, Sensitivity and Specificity, Severity of Illness Index, Cohort Studies, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Severity of illness, Prevalence, medicine, Humans, Amyotrophic lateral sclerosis, Survival analysis, Aged, Proportional Hazards Models, Proportional hazards model, business.industry, Amyotrophic Lateral Sclerosis, Reproducibility of Results, Middle Aged, Prognosis, medicine.disease, Survival Analysis, Clinical trial, Italy, Neurology, Cohort, Physical therapy, Female, Neurology (clinical), business, Body mass index, 030217 neurology & neurosurgery, Cohort study |
| الوصف: | Our objectives were: (1) to identify independent prognostic factors to determine a survival score for amyotrophic lateral sclerosis (ALS) in a cohort of patients followed in the NEMO Centre (NEuroMuscular Omnicentre); (2) to replicate results in an independent cohort obtained from the Pooled Resource Open Access ALS Clinical Trial Consortium (PRO-ACT) database. Samples were collected from 428 ALS patients from the NEMO database and 2481 patients from the PRO-ACT database. Study design was a retrospective analysis with clinical and biochemical variables, using univariable and multivariable Cox models of analysis. Results showed that, in multivariable analysis, age at diagnosis, diagnostic delay, ALSFRS-R total score, Body Mass Index, aspartate aminotransferase and creatinine level were independently related to survival. These factors were recoded as categorical variables assigning a score from 5 to 15, and the sums of these scores were used to obtain the ALS-Survival Score (ALS-SS). This then allowed to identify three groups having different survival curves. The ALS-SS results were also replicated using data from the PRO-ACT database. In conclusion, considering independent prognostic factors, we were able to give an estimate of survival in our cohort of ALS patients. Whether this ALS-SS may be useful in clinical practice, and potentially in clinical trials, will have to be determined prospectively. |
| تدمد: | 2167-9223 2167-8421 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a58ea3df371041a45cec67ab51be894Test https://doi.org/10.3109/21678421.2015.1083585Test |
| رقم الانضمام: | edsair.doi.dedup.....2a58ea3df371041a45cec67ab51be894 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21679223 21678421 |
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