Clinical epidemiology of amyotrophic lateral sclerosis in Liguria, Italy: An update of LIGALS register
| العنوان: | Clinical epidemiology of amyotrophic lateral sclerosis in Liguria, Italy: An update of LIGALS register |
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| المؤلفون: | Monica Bandettini di Poggio, Paola Mandich, Claudia Caponnetto, Antonio Canosa, Romina Truffelli, Paola Origone, Carlo Scialò, Giovanni Novi, Giovanni Luigi Mancardi, Maria Pia Sormani |
| المصدر: | Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 17:535-542 |
| بيانات النشر: | Informa UK Limited, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, medicine.medical_specialty, Pediatrics, Population, Prevalence, Clinical epidemiology, survival, 03 medical and health sciences, 0302 clinical medicine, Surveys and Questionnaires, Epidemiology, medicine, Humans, Longitudinal Studies, Registries, Amyotrophic lateral sclerosis, education, Survival analysis, Aged, Retrospective Studies, Aged, 80 and over, Analysis of Variance, education.field_of_study, C9orf72 Protein, business.industry, Incidence (epidemiology), Proteins, Retrospective cohort study, Middle Aged, medicine.disease, Survival Analysis, Surgery, DNA-Binding Proteins, 030104 developmental biology, Italy, Neurology, epidemiology, incidence, motor neuron disease, Neurology (clinical), Mutation, Female, business, 030217 neurology & neurosurgery |
| الوصف: | Our objectives were: (1) to assess amyotrophic lateral sclerosis (ALS) incidence and its trend over time in Liguria, an Italian north-western region, performing an analysis of data prospectively collected from 1 January 2009 to 31 December 2014; (2) to determine the mean and median survival in the 2009-2014 Ligurian ALS incident cases; and (3) to evaluate the presence of disease prognostic factors. The Liguria Register for ALS (LIGALS) is an ongoing, multicentre prospective register enrolling all ALS incident cases in Liguria. Cases were identified using several concurrent sources. ALS diagnosis was based on El Escorial revised criteria (EEC-R). Two hundred and ninety-eight patients were enrolled in this study. The mean annual crude incidence rate in the 2009-2014 period was 3.11/100,000 population (95% CI 2.77-3.49); the point prevalence at 31 December 2014 was 7.85/100,000 (95% CI 6.54-9.36) population. Survival analysis demonstrated a median survival from symptom onset of 37.0 months (95% CI 32.0-42.0). In conclusion, ALS crude incidence in Liguria is higher compared to other Italian regions. Clinical and epidemiological data are comparable with those of the Italian ALS population. Survival analysis showed that higher age at onset, bulbar onset, definite EEC-R diagnostic category and a shorter diagnostic delay are related with worse outcomes. |
| تدمد: | 2167-9223 2167-8421 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d0dad6e09e01e1d8566143d6162c90Test https://doi.org/10.1080/21678421.2016.1197942Test |
| حقوق: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....29d0dad6e09e01e1d8566143d6162c90 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21679223 21678421 |
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