التفاصيل البيبلوغرافية
| العنوان: |
Changes in nerve excitability indices in hereditary transthyretin amyloidosis. |
| المؤلفون: |
Yamashita, Taro, Ueda, Mitsuharu, Misawa, Sonoko, Inoue, Yasuteru, Masuda, Teruaki, Misumi, Yohei, Takamatsu, Kotaro, Obayashi, Konen, Kuwabara, Satoshi, Ando, Yukio |
| المصدر: |
Amyloid; 2019 Supplement 1, Vol. 26, p9-10, 2p |
| مصطلحات موضوعية: |
CARDIAC amyloidosis, NERVES, AMYOTROPHIC lateral sclerosis |
| مستخلص: |
Highlights from the article: Hereditary transthyretin (ATTR, ATTRm) amyloidosis, which is also called transthyretin-type familial amyloid polyneuropathy (ATTR-FAP), is a life-threatening, autosomal dominant systemic amyloidosis caused by mutant transthyretin (TTR) [[1]]. Hyperpolarization under threshold by reduced persistent sodium current in the motor axons of patients with ATTRm amyloidosis was observed, which suggests an abnormal slow potassium channel and increased sodium-potassium pump activity. The nerve excitability test may serve as a practical tool for monitoring the progress of ATTRm amyloidosis. |
| قاعدة البيانات: |
Complementary Index |
