Dietary GABA induces endogenous synthesis of a novel imidazole peptide homocarnosine in mouse skeletal muscles
| العنوان: | Dietary GABA induces endogenous synthesis of a novel imidazole peptide homocarnosine in mouse skeletal muscles |
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| المؤلفون: | Mikako Sato, Takumi Komaru, Noriyuki Yanaka, Thanutchaporn Kumrungsee, Yasuyuki Oishi, Ai S. Egusa, Takeshi Arima, Kanako Sato |
| المصدر: | Amino Acids. 52:743-753 |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, medicine.medical_specialty, GABA Agents, Clinical Biochemistry, Anserine, Carnosine, Peptide, Endogeny, Biochemistry, Vigabatrin, Mice, 03 medical and health sciences, GABA transaminase, chemistry.chemical_compound, Internal medicine, medicine, Animals, Muscle, Skeletal, gamma-Aminobutyric Acid, chemistry.chemical_classification, Mice, Inbred ICR, Dipeptide, 030102 biochemistry & molecular biology, Organic Chemistry, Imidazoles, Skeletal muscle, Feeding Behavior, Diet, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, nervous system, chemistry, beta-Alanine, medicine.drug |
| الوصف: | Carnosine (β-alanyl-l-histidine) is an imidazole dipeptide present at high concentrations in skeletal muscles, where it plays a beneficial role. However, oral intake of carnosine or β-alanine to increase skeletal muscle carnosine levels has disadvantages such as low efficiency and side effects. Therefore, we proposed homocarnosine (γ-aminobutyryl-l-histidine) as a novel alternative imidazole peptide for skeletal muscle based on its structural similarity to carnosine. To induce endogenous homocarnosine synthesis in skeletal muscles, mice were fed a basal diet mixed with 0, 0.5, 2, or 5% γ-aminobutyric acid (GABA) for 6 weeks. As expected, in the control group (0% GABA), GABA and homocarnosine were present in trace concentrations. Skeletal muscle homocarnosine levels were significantly increased in the 2% and 5% GABA intake groups (tenfold, P |
| تدمد: | 1438-2199 0939-4451 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94eca6193ae95e068afdb2d366f3f35Test https://doi.org/10.1007/s00726-020-02848-xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....e94eca6193ae95e068afdb2d366f3f35 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14382199 09394451 |
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