Acute regulation of IGF-I by alterations in post-exercise macronutrients
| العنوان: | Acute regulation of IGF-I by alterations in post-exercise macronutrients |
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| المؤلفون: | David D. Pascoe, J. L. Sartin, W. Cowan, Gordon Fisher, T. H. Elsasser, Ernest B. Foster, Guoyao Wu |
| المصدر: | Amino Acids. 42:1405-1416 |
| بيانات النشر: | Springer Science and Business Media LLC, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Clinical Biochemistry, Carbohydrate metabolism, Hematocrit, Biochemistry, Interval training, Young Adult, Internal medicine, medicine, Humans, Insulin, Insulin-Like Growth Factor I, Exercise, Essential amino acid, chemistry.chemical_classification, medicine.diagnostic_test, Organic Chemistry, Carbohydrate, Insulin-Like Growth Factor Binding Protein 1, Insulin-Like Growth Factor Binding Protein 2, Endocrinology, Gene Expression Regulation, chemistry, Growth Hormone, Dietary Supplements, Carbohydrate Metabolism, Amino Acids, Essential, Hemoglobin, Leucine |
| الوصف: | This investigation sought to examine the contributions of exercise and nutrient replenishment on in vivo regulation of the insulin-like growth factor-I (IGF-I) axis components. Eight college-aged males completed three high-intensity interval training (HIIT) protocols followed by three post-exercise nutritional protocols: (1) placebo (EX); (2) carbohydrate only (CHO); and (3) essential amino acid/carbohydrate (EAA/CHO). Samples were analyzed for growth hormone (GH), free IGF-I, IGFBP-1, IGFBP-2, insulin, hematocrit, hemoglobin, serum leucine, matrix metalloproteinase-9 (MMP-9) proteolytic activity, and presence of IGFBP-3 protease activity. No evidence for IGFBP-3 proteolysis was observed. Significant increases in [free IGF-I] and [leucine] were observed in the EAA/CHO group only. Significant differences were noted in [IGFBP-1] and [IGFBP-2] across conditions. Significant increases in [GH] and MMP-9 activity were observed in all groups. These results indicate that post-exercise macronutrient ratio is a determinant of [free IGF-I], [IGFBP-1 and -2] and may play a role in modulating the IGF-I axis in vivo. |
| تدمد: | 1438-2199 0939-4451 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fab1074ca3f37a7209cfb46f4aee26b6Test https://doi.org/10.1007/s00726-011-0837-yTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....fab1074ca3f37a7209cfb46f4aee26b6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14382199 09394451 |
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