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Direct-acting antivirals are effective and safe in HCV/HIV-coinfected liver transplant recipients who experience recurrence of hepatitis C: A prospective nationwide cohort study

التفاصيل البيبلوغرافية
العنوان: Direct-acting antivirals are effective and safe in HCV/HIV-coinfected liver transplant recipients who experience recurrence of hepatitis C: A prospective nationwide cohort study
المؤلفون: Federico Pulido, Ferran Torres, ALBERTO VENTOSO, Valentín Cuervas-Mons, Pedro Lopez Cillero, Víctor Asensi Álvarez, Carolina Almohalla, Rosa JORBA, Ramon Charco, José Antonio Pons-Miñano, Carme Baliellas, Pilar Barrera Baena, Rafael Bañares, Isabel Campos Varela, Gonzalo Crespo, Montse Tuset, M. Trinidad Serrano Aulló, Manuel Rodriguez, Josep Mallolas Masferrer, Antonio Rivero Román, Santos Del Campo, Constantino Fondevila, Pilar Martín-Dávila, Juan González-García, Carlos Cervera, Victor Manuel Vargas Blasco, Oscar Len, María Pilar Alonso García, Jesus Fortun, MARIA VICTORIA AGUILERA SANCHO-TELLO, Gloria Sanchez Antolin, Montserrat Laguno Centeno, José Miguel Cisneros, Jorge Calvo, Jordi Carratala, Xavier Forns, Rafael Rubio García, Antonio Rivero, Asunción Moreno Camacho, Elisa Cordero, Xavier Xiol, Emilio Fábrega
المصدر: AMERICAN JOURNAL OF TRANSPLANTATION
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
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بيانات النشر: Elsevier BV, 2018.
سنة النشر: 2018
مصطلحات موضوعية: Male, Human immunodeficiency virus (HIV), HIV Infections, Hepacivirus, 030230 surgery, medicine.disease_cause, DIRECT ACTING ANTIVIRALS, human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) [infection and infectious agents-viral], Gastroenterology, chemistry.chemical_compound, 0302 clinical medicine, Recurrence, Genotype, Immunology and Allergy, Medicine, Pharmacology (medical), Prospective Studies, liver transplantation, Coinfection, virus diseases, Hepatitis C, Middle Aged, Prognosis, practice, human immunodeficiency virus (HIV) [infection and infectious agentsviral], hepatitis C [infection and infectious agentsviral], Tolerability, Drug Therapy, Combination, Female, 030211 gastroenterology & hepatology, Cohort study, medicine.medical_specialty, Hepatitis C virus, clinical research/practice, Antiviral Agents, 03 medical and health sciences, Internal medicine, Humans, acquired immunodeficiency syndrome (AIDS), Transplantation, business.industry, Ribavirin, HIV, medicine.disease, Transplant Recipients, digestive system diseases, Liver Transplantation, clinical research, chemistry, hepatology, hepatitis C [infection and infectious agents-viral], business, liver transplantation/hepatology, Follow-Up Studies
الوصف: Direct-acting antivirals have proved to be highly efficacious and safe in monoinfected liver transplant (LT) recipients who experience recurrence of hepatitis C virus (HCV) infection. However, there is a lack of data on effectiveness and tolerability of these regimens in HCV/HIV-coinfected patients who experience recurrence of HCV infection after LT. In this prospective, multicenter cohort study, the outcomes of 47 HCV/HIV-coinfected LT patients who received DAA therapy (with or without ribavirin [RBV]) were compared with those of a matched cohort of 148 HCV-monoinfected LT recipients who received similar treatment. Baseline characteristics were similar in both groups. HCV/HIV-coinfected patients had a median (IQR) CD4 T-cell count of 366 (256-467) cells/mu L. HIV-RNA was
تدمد: 1600-6135
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61c865b66bb172d05cb420286c0e79c0Test
https://doi.org/10.1111/ajt.14996Test
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....61c865b66bb172d05cb420286c0e79c0
قاعدة البيانات: OpenAIRE
الوصف
تدمد:16006135