Postmortem Findings Associated With SARS-CoV-2
| العنوان: | Postmortem Findings Associated With SARS-CoV-2 |
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| المؤلفون: | Satturwar, Swati, Fowkes, Mary, Farver, Carol, Wilson, Allecia M., Eccher, Albino, Girolami, Ilaria, Pujadas, Elisabet, Bryce, Clare, Salem, Fadi, El Jamal, Siraj M., Paniz-Mondolfi, Alberto, Petersen, Bruce, Gordon, Ronald E., Reidy, Jason, Fraggetta, Filippo, Marshall, Desiree A., Pantanowitz, Liron |
| المصدر: | American Journal of Surgical Pathology The American Journal of Surgical Pathology |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Myocardium, coronavirus, SARS-CoV-1, COVID-19, Brain, Original Articles, Global Health, Kidney, Severe Acute Respiratory Syndrome, Pathology and Forensic Medicine, autopsy, Case-Control Studies, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Humans, pathology, Surgery, Anatomy, Lung, Spleen |
| الوصف: | Supplemental Digital Content is available in the text. Coronavirus Disease 2019 (COVID-19), caused by the novel Severe Acute Respiratory Syndrome–associated Coronavirus 2 (SARS-CoV-2), has become a global threat to public health. COVID-19 is more pathogenic and infectious than the prior 2002 pandemic caused by SARS-CoV-1. The pathogenesis of certain disease manifestations in COVID-19 such as diffuse alveolar damage (DAD) are thought to be similar to SARS-CoV-1. However, the exact pathogenesis of COVID-19 related deaths remains poorly understood. The aim of this article was to systematically summarize the rapidly emerging literature regarding COVID-19 autopsies. A meta-analysis was also conducted based on data accrued from preprint and published articles on COVID-19 (n=241 patients) and the results compared with postmortem findings associated with SARS-CoV-1 deaths (n=91 patients). Both autopsy groups included mostly adults of median age 70 years with COVID-19 and 50 years with SARS-CoV-1. Overall, prevalence of DAD was more common in SARS-CoV-1 (100.0%) than COVID-19 (80.9%) autopsies (P=0.001). Extrapulmonary findings among both groups were not statistically significant except for hepatic necrosis (P |
| اللغة: | English |
| تدمد: | 0147-5185 |
| DOI: | 10.1097/pas.0000000000001650 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::24f457d98f8e43e0179242387e9fb8b5Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid.dedup....24f457d98f8e43e0179242387e9fb8b5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 01475185 |
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| DOI: | 10.1097/pas.0000000000001650 |