التفاصيل البيبلوغرافية
| العنوان: |
Relationship between Cervical Mucus Interleukin-8 Concentrations and Vaginal Bacteria in Pregnancy. |
| المؤلفون: |
Sakai, Masatoshi, Ishiyama, Akihiko, Tabata, Mika, Sasaki, Yasushi, Yoneda, Satoshi, Shiozaki, Arihiro, Saito, Shigeru |
| المصدر: |
American Journal of Reproductive Immunology; Aug2004, Vol. 52 Issue 2, p106-112, 7p, 6 Charts |
| مصطلحات موضوعية: |
INTERLEUKIN-8, INTERLEUKINS, CERVIX mucus, PATHOGENIC microorganisms, INFANTS |
| مستخلص: |
PROBLEM: High interleukin (IL)-8 concentration in cervical mucus in the second trimester is a risk factor for premature birth. We investigated the relationship between vaginal pathogens and IL-8 in cervical mucus. METHOD OF STUDY: In 501 women with single pregnancy, vaginal secretions were cultured for bacteria and cervical mucus IL-8 concentrations were measured between 20 and 24 gestational weeks. RESULTS: Lactobacillus species were detected in 56.0% of 84 subjects with high IL-8 (≥ 377 ng/mL), significantly less often than in 417 subjects with IL-8 below 377 ng/mL (84.7%; P < 0.0001). Anaerobic pathogens were detected in 83.3% of high IL-8 subjects, significantly more often than in normal IL-8 subjects (43.9%; P < 0.0001). By multivariate analysis, cervical IL-8 was significantly high only in subjects without Lactobacillus species; they showed a significantly higher prematurity rate than Lactobacillus - positive subjects. CONCLUSIONS: Absence of vaginal Lactobacillus was associated with increased cervical IL-8 and increased risk of premature delivery. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
