Long‐term effects of castration on the skeleton of male rhesus monkeys ( Macaca mulatta )
| العنوان: | Long‐term effects of castration on the skeleton of male rhesus monkeys ( Macaca mulatta ) |
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| المؤلفون: | Terry B. Kensler, Kelly F Ethun, Jeffrey Wimsatt, Marc D. Grynpas, Kenneth P.H. Pritzker, M. J. Kessler, Olga D. Gonzalez Velez, Qian Wang, Richard G. Rawlins, Antonietta M. Cerroni |
| المصدر: | American Journal of Primatology. 78:152-166 |
| بيانات النشر: | Wiley, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, musculoskeletal diseases, 0301 basic medicine, medicine.medical_specialty, Bone density, Osteoporosis, Article, 03 medical and health sciences, chemistry.chemical_compound, Absorptiometry, Photon, Bone Density, Internal medicine, biology.animal, medicine, Animals, Primate, Femur, Orchiectomy, Ecology, Evolution, Behavior and Systematics, Lumbar Vertebrae, biology, Puerto Rico, Skull, medicine.disease, biology.organism_classification, Macaca mulatta, Skeleton (computer programming), Radiographic Image Enhancement, Osteopenia, Rhesus macaque, 030104 developmental biology, Endocrinology, Castration, chemistry, Autoradiography, Animal Science and Zoology |
| الوصف: | While osteopenia (OPE) and osteoporosis (OPO) have been studied in various species of aging nonhuman primates and extensively in ovariectomized rhesus and cynomolgus macaques, there is virtually no information on the effects of castration on the skeleton of male nonhuman primates. Most information on castrated male primates comes from a few studies on the skeletons of eunuchs. This report used a subset of the Caribbean Primate Research Center's (CPRC) Cayo Santiago (CS) rhesus macaque skeletal collection to qualitatively and quantitatively compare the bone mineral density (BMD) of castrated and age-matched intact males and, thereby, determine the long-term effects of castration (orchidectomy) on bone. Lumbar vertebrae, femora, and crania were evaluated using dual-energy X-ray absorptiometry (DEXA or DXA) and digital radiography augmented, when fresh tissues were available, with autoradiography and histology. Results confirmed physical examinations of long bones that castration causes changes in the skeleton of male rhesus macaques similar to those found in eunuchs, including OPE and OPO of the vertebrae and femora, thinning of the skull, and vertebral fractures and kyphosis of the spine more severe than that caused by normal aging alone. Also like eunuchs, some castrated CS male rhesus monkeys had a longer life span than intact males or females. Based on these results and the effects of castration on other tissues and organs of eunuchs, on behavior, hormone profiles and possibly on cognition and visual perception of human and nonhuman primates, and other mammals, castrated male rhesus macaques should be used with caution for laboratory studies and should be considered a separate category from intact males. Despite these caveats, the castrated male rhesus macaque should make an excellent animal model in which to test hormone replacement therapies for boys and men orchidectomized for testicular and prostate cancer. |
| تدمد: | 1098-2345 0275-2565 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::953e17a51efff6d4c6fce85653d77accTest https://doi.org/10.1002/ajp.22399Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....953e17a51efff6d4c6fce85653d77acc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10982345 02752565 |
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