Orthodontic tooth movement and root resorption in ovariectomized rats treated by systemic administration of zoledronic acid
| العنوان: | Orthodontic tooth movement and root resorption in ovariectomized rats treated by systemic administration of zoledronic acid |
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| المؤلفون: | Carmen Gonzales, Hitoshi Hotokezaka, Noriaki Yoshida, Irin Sirisoontorn, M. Ali Darendeliler, Suwannee Luppanapornlarp, Megumi Hashimoto |
| المصدر: | American Journal of Orthodontics and Dentofacial Orthopedics. 141(5):563-573 |
| بيانات النشر: | Mosby Inc., 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | medicine.medical_specialty, Tooth Movement Techniques, medicine.medical_treatment, Osteoporosis, periodontal disease, Root Resorption, Dentistry, Orthodontics, Root resorption, Wistar rat, Tooth Movement, zoledronic acid, Internal medicine, medicine, Animals, animal, rat, bisphosphonic acid derivative, Rats, Wistar, tooth disease, comparative study, bone density conservation agent, Bone Density Conservation Agents, Diphosphonates, business.industry, disease model, Imidazoles, article, Bisphosphonate, medicine.disease, osteoporosis, Rats, Disease Models, Animal, postmenopause, Zoledronic acid, Endocrinology, female, Tooth movement, Ovariectomized rat, Systemic administration, imidazole derivative, business, medicine.drug |
| الوصف: | Introduction: The effect of zoledronic acid, a potent and novel bisphosphonate, on tooth movement and orthodontically induced root resorption in osteoporotic animals systemically treated with zoledronic acid as similarly used in postmenopausal patients has not been elucidated. Therefore, this study was undertaken. Methods: Fifteen 10-week-old female Wistar rats were divided into 3 groups: ovariectomy, ovariectomy + zoledronic acid, and control. Only the ovariectomy and ovariectomy + zoledronic acid groups underwent ovariectomies. Two weeks after the ovariectomy, zoledronic acid was administered only to the ovariectomy + zoledronic acid group. Four weeks after the ovariectomy, 25-g nickel-titanium closed-coil springs were applied to observe tooth movement and orthodontically induced root resorption. Results: There were significant differences in the amounts of tooth movement and orthodontically induced root resorption between the ovariectomy and the control groups, and also between the ovariectomy and the ovariectomy + zoledronic acid groups. There was no statistically significant difference in tooth movement and orthodontically induced root resorption between the ovariectomy + zoledronic acid and the control groups. Zoledronic acid inhibited significantly more tooth movement and significantly reduced the severity of orthodontically induced root resorption in the ovariectomized rats. The ovariectomy + zoledronic acid group showed almost the same results as did the control group in both tooth movement and orthodontically induced root resorption. Conclusions: Zoledronic acid inhibits excessive orthodontic tooth movement and also reduces the risk of severe orthodontically induced root resorption in ovariectomized rats. American Journal of Orthodontics and Dentofacial Orthopedics, 141(5), pp.563-573; 2012 |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0889-5406 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7896d8888901a82f9634e08dd2cd47f3Test https://nagasaki-u.repo.nii.ac.jp/records/9295Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7896d8888901a82f9634e08dd2cd47f3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 08895406 |
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