التفاصيل البيبلوغرافية
| العنوان: |
Plasma lead concentration and risk of late kidney allograft failure: findings from the transplantlines biobank and cohort studies |
| المؤلفون: |
Sotomayor Campos, Camilo Germán, Giubergia Cánepa, Flavia Marta Grace, Groothof, Dion, Ferreccio Readi, Fresia Catterina, Nolte, Ilja M., Navis, Gerjan J., Gomes Neto, Antonio W., Kremer, Daan, Knobbe, Tim J., Eisenga, Michele F., Rodrigo Salinas, Ramón Aníbal, Touw, Daan J., Bakker, Stephan J.L. |
| المصدر: |
American Journal of Kidney Diseases |
| بيانات النشر: |
W B Saunders Co-Elsevier |
| سنة النشر: |
2022 |
| المجموعة: |
Universidad de Chile: Repositorio académico |
| مصطلحات موضوعية: |
Induced oxidative stress, Blood lead, Chelation-therapy, Renal-function, United States, Exposure, Toxicity, Cadmium, Bone |
| الوصف: |
Rationale & Objective: Heavy metals are known to induce kidney damage, and recent studies have linked minor exposures to cadmium and arsenic with increased risk of kidney allograft failure, yet the potential association of lead with late graft failure in kidney transplant recipients (KTRs) remains unknown. ; Study Design: Prospective cohort study in The Netherlands. ; Setting & Participants: We studied outpatient KTRs (n = 670) with a functioning graft for ≥1 year recruited at a university setting (2008-2011) and followed for a median of 4.9 (interquartile range, 3.4-5.5) years. Additionally, patients with chronic kidney disease (n = 46) enrolled in the ongoing TransplantLines Cohort and Biobank Study (2016-2017, ClinicalTrials.gov identifier NCT03272841) were studied at admission for transplant and at 3, 6, 12, and 24 months after transplant. ; Exposure: Plasma lead concentration was log2- transformed to estimate the association with outcomes per doubling of plasma lead concentration and also considered categorically as tertiles of lead distribution. ; Outcome: Kidney graft failure (restart of dialysis or repeat transplant) with the competing event of death with a functioning graft. ; Analytical Approach: Multivariable-adjusted cause-specific hazards models in which follow-up of KTRs who died with a functioning graft was censored. ; Results: Median baseline plasma lead concentration was 0.31 (interquartile range, 0.22-0.45) μg/L among all KTRs. During follow-up, 78 (12%) KTRs experienced graft failure. Higher plasma lead concentration was associated with increased risk of graft failure (hazard ratio, 1.59 [95% CI, 1.14- 2.21] per doubling; P = 0.006) independent of age, sex, transplant characteristics, estimated glomerular filtration rate, proteinuria, smoking status, alcohol intake, and plasma concentrations of cadmium and arsenic. These findings remained materially unchanged after additional adjustment for dietary intake and were consistent with those of analyses examining lead categorically. In ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Am J Kidney Dis. 80 (1): 87-97; https://repositorio.uchile.cl/handle/2250/195299Test |
| الإتاحة: |
https://repositorio.uchile.cl/handle/2250/195299Test |
| حقوق: |
Attribution-NonCommercial-NoDerivs 3.0 United States ; http://creativecommons.org/licenses/by-nc-nd/3.0/usTest/ |
| رقم الانضمام: |
edsbas.A9DDB420 |
| قاعدة البيانات: |
BASE |
