دورية
A029: Midwall shortening fraction, left ventricular mass and prognosis in essential hypertension
| العنوان: | A029: Midwall shortening fraction, left ventricular mass and prognosis in essential hypertension |
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| المؤلفون: | Verdecchia, P., Schillaci, G., Reboldi, G., Ambrosio, G., Porcellati, C. |
| المصدر: | American Journal of Hypertension; April 2000, Vol. 13 Issue: Supplement 2 p50A-50A, 1p |
| مستخلص: | A link has been suggested between left ventricular (LV) midwall shortening (MWS) and risk of cardiovascular (CV) disease in essential hypertension. To further address this issue, we followed 1778 subjects with essential hypertension for up to 12 years (mean, 4.3). At entry, all subjects were untreated and underwent echocardiography and 24-h ambulatory blood pressure monitoring. Treatment was tailored to the single patient. Outcome measures were CV morbidity, CV mortality and all-cause mortality. At entry, there was a significant inverse association (r = -0.44; p < 0.0001) between MWS and LV mass. During follow-up there were 166 CV events and 53 all-cause deaths. CV morbidity (events per 100 patient-years) in the 4 quartiles of MWS was 1.48, 2.09, 2.13 and 3.07 (p < 0.01). In multivariate analysis, age, sex, diabetes and 24-h pulse pressure were independent predictors of CV morbidity and addition of either LV mass or MWS, alone or combined with their interaction term, produced a further improvement in the risk prediction (all p < 0.01). When LV mass and MWS were both forced into the model, only LV mass achieved significance (p = 0.02). CV mortality and all-cause mortality showed an independent association with LV mass, but not with MWS. In conclusion, left ventricular mass and midwall shortening are associated variables in asymptomatic adult subjects with essential hypertension. The independent prognostic value of left ventricular mass is slightly but significantly superior to that of midwall shortening. (See |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 08957061 19417225 |
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| DOI: | 10.1016/S0895-7061(00)00421-0 |