Bacterial toxins and enteral feeding of premature infants at risk for necrotizing enterocolitis
| العنوان: | Bacterial toxins and enteral feeding of premature infants at risk for necrotizing enterocolitis |
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| المؤلفون: | Maria Zielezny, Frederick C. Morin, Diane Dryja, Linda C. Duffy, Milo Hilty, Vivien Carrion, Elizabeth Griffiths, James J. Cummings |
| المصدر: | American Journal of Human Biology. 10:211-219 |
| بيانات النشر: | Wiley, 1998. |
| سنة النشر: | 1998 |
| مصطلحات موضوعية: | Gastrointestinal tract, Pediatrics, medicine.medical_specialty, Nothing by mouth, Neonatal intensive care unit, business.industry, medicine.medical_treatment, Disease, Breast milk, medicine.disease, Enteral administration, Gastroenterology, digestive system diseases, Anthropology, Internal medicine, Necrotizing enterocolitis, Cohort, Genetics, medicine, Anatomy, business, Ecology, Evolution, Behavior and Systematics |
| الوصف: | Bacterial translocation and enteral feeding are factors implicated in neonatal necrotizing enterocolitis (NEC) in the preterm infant. A cohort of 60 preterm low birth-weight (LBW) infants (600-1,600 g at birth) consecutively admitted to the neonatal intensive care unit (NICU; N = 183) were prospectively followed to evaluate the role of bacterial endotoxins (lipopolysaccharides) and enteral feeding in the development of NEC. Stage I NEC was identified in 14/60 (23%) infants. In all, 15% (9/60) of infants followed, which represented roughly 5% of higher risk, LBW infants admitted to the NICU, progressed to Stage II or III NEC disease. Infants not enterally fed (nothing by mouth [NPO]) were at greatest risk of developing NEC. No infant who was breast milk fed progressed to Stage II or III NEC. The protective effect of breast milk was most evident when compared with the combined group of NPO or formula-feeding infants per person-week at risk (RR = .15, P < .04). Toxin-producing bacteria and endotoxin levels in stool filtrates predicted early and advanced stages of NEC disease. Cytokine concentrations (interleukin-6 [IL-6]) in stool appeared of limited value in reflecting mucosally limited disease in the gastrointestinal tract. Overgrowth of toxin-producing bacteria and their toxin products may adversely affect gut barrier function; monitoring endotoxin concentrations in stool filtrates may be most clinically useful in NPO and formula-fed infants identified at risk of developing NEC. Am. J. Hum. Biol. 10:211-219, 1998. © 1998 Wiley-Liss, Inc. |
| تدمد: | 1520-6300 1042-0533 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::74008cacd748d74b72ffee544e714f2eTest https://doi.org/10.1002Test/(sici)1520-6300(1998)10:2<211::aid-ajhb6>3.0.co;2-n |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........74008cacd748d74b72ffee544e714f2e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15206300 10420533 |
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