التفاصيل البيبلوغرافية
| العنوان: |
Clinical features of hepatocellular carcinoma seronegative for both HBsAg and anti-HCV antibody but positive for anti-HBc antibody in Japan |
| المؤلفون: |
Yano, Yoichi, Yamashita, Fumihiko, Sumie, Shuji, Ando, Eiji, Fukumori, Kazuta, Kiyama, Masahiro, Oyama, Takashi, Kuroki, Shigetaka, Kato, Osamu, Yamamoto, Hiroshi, Tanaka, Masatoshi, Sata, Michio |
| المصدر: |
American Journal of Gastroenterology (Springer Nature); Jan2002, Vol. 97 Issue 1, p156, 6p |
| مصطلحات موضوعية: |
HEALTH surveys, LIVER cancer |
| مصطلحات جغرافية: |
JAPAN |
| مستخلص: |
OBJECTIVE:We determined the prevalence of patients with hepatocellular carcinoma (HCC) who were positive for only anti-hepatitis B core (anti-HBc) antibody among 284 Japanese patients and compared their clinical features to those who were hepatitis B surface antigen positive [HBsAg (+)].METHODS:Serum HBsAg and anti-hepatitis C virus (anti-HCV) antibody were examined for all HCC patients. Testing for anti-HBc antibody was performed in the HBsAg(−)/anti-HCV(−) patients. The clinical factors and the survival rate were compared between the HBsAg(+) patients (HCC-B) and those positive for anti-HBc alone (HCC-PB).RESULTS:There were 19 (6.7%) HBsAg(+), 236 (83.1%) anti-HCV(+), seven (2.5%) HBsAg(+)/anti-HCV(+), and 22 (7.7%) HBsAg(−)/anti-HCV(−) among the 284 patients tested. Sixteen (72.7%) of the 22 HBsAg(−)/anti-HCV(−) patients were assigned to the HCC-PB group. The prevalence of positivity for anti-HBc alone among all 284 HCC patients was 5.6%. Significant differences between the HCC-PB and HCC-B groups were that age at diagnosis was higher in the HCC-PB group (72.1 yr) than in the HCC-B group (56.2 yr) (p < 0.001), the serum α-fetoprotein concentrations were lower in the HCC-PB group (8.2 ng/ml) than in the HCC-B group (43 ng/ml) (p = 0.0488), and a higher familial history of liver disease was observed in the HCC-B group (p = 0.0373). However, there was no significant difference in the cumulative survival rate.CONCLUSIONS:Positivity for anti-HBc alone is not rare compared to HBsAg(+), and the clinical features of positivity for anti-HBc alone are similar to those of HBsAg(+). Some differences in the clinical features between the two groups may be explained by differences in the time of first exposure to hepatitis B virus. Therefore, the natural course of acute hepatitis B may be reconsidered. [Copyright &y& Elsevier] |
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| قاعدة البيانات: |
Complementary Index |
