دورية أكاديمية
Unsaturated Iron Binding capacity and Transferrin saturation are equally reliable in detection of HFE hemochromatosis
| العنوان: | Unsaturated Iron Binding capacity and Transferrin saturation are equally reliable in detection of HFE hemochromatosis |
|---|---|
| المؤلفون: | Murtagh, L, Whiley, Michael, Wilson, Susan, Tran, Huy Anh, Bassett, Mark L |
| المصدر: | American Journal of Gastroenterology |
| بيانات النشر: | Elsevier |
| المجموعة: | Australian National University: ANU Digital Collections |
| مصطلحات موضوعية: | Keywords: ferritin, transferrin, article, clinical feature, clinical trial, controlled clinical trial, controlled study, correlation analysis, diagnostic accuracy, diagnostic value, family history, gene expression, gene mutation, genetic predisposition, genotype |
| الوصف: | OBJECTIVE: Unsaturated iron binding capacity (UIBC) has been proposed as an inexpensive alternative to transferrin saturation for detection of hereditary hemochromatosis. The aim of this study was to compare, in a hospital referral clinic, the reliability of transferrin saturation and UIBC for detection of subjects who have inherited HFE (HLA-asociated iron overload) genotypes predisposing to iron overload. METHODS: Serum transferrin saturation, UIBC, and ferritin were tested in 110 consecutive subjects. Optimum thresholds were determined from receiver operating characteristic curves. RESULTS: Of 110 subjects, 44 carried significant HFE mutations (C282Y/C282Y or C282Y/H63D). In genetically predisposed subjects with biochemical expression, the optimum threshold for transferrin saturation was 43%, giving a sensitivity of 0.88 and specificity 0.95. For UIBC, the optimum threshold was 143 μg/dL (25.6 μmol/L), giving a sensitivity of 0.91 and specificity of 0.95. In patients referred with a family history or clinical suspicion of hemochromatosis, transferrin saturation and UIBC were highly reliable predictors of genotype. In patients referred for investigation of abnormal liver enzymes without a known family history of hemochromatosis, a normal transferrin saturation or normal UIBC was highly reliable in excluding hemochromatosis. CONCLUSIONS: Transferrin saturation and UIBC have equal reliability in ability to predict hemochromatosis. UIBC should be considered as an alternative to transferrin saturation in detection of hemochromatosis. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 0002-9270 |
| العلاقة: | http://hdl.handle.net/1885/94258Test; https://openresearch-repository.anu.edu.au/bitstream/1885/94258/5/MigratedxPub23796_2002.pdf.jpgTest; https://openresearch-repository.anu.edu.au/bitstream/1885/94258/7/01_Murtagh_Unsaturated_Iron_Binding_2002.pdf.jpgTest |
| DOI: | 10.1016/S0002-9270(02)04284-3 |
| الإتاحة: | https://doi.org/10.1016/S0002-9270Test(02)04284-3 http://hdl.handle.net/1885/94258Test https://openresearch-repository.anu.edu.au/bitstream/1885/94258/5/MigratedxPub23796_2002.pdf.jpgTest https://openresearch-repository.anu.edu.au/bitstream/1885/94258/7/01_Murtagh_Unsaturated_Iron_Binding_2002.pdf.jpgTest |
| رقم الانضمام: | edsbas.BD1FE184 |
| قاعدة البيانات: | BASE |
| تدمد: | 00029270 |
|---|---|
| DOI: | 10.1016/S0002-9270(02)04284-3 |