Two Epstein-Barr Virus-Related Serologic Antibody Tests in Nasopharyngeal Carcinoma Screening: Results From the Initial Phase of a Cluster Randomized Controlled Trial in Southern China
| العنوان: | Two Epstein-Barr Virus-Related Serologic Antibody Tests in Nasopharyngeal Carcinoma Screening: Results From the Initial Phase of a Cluster Randomized Controlled Trial in Southern China |
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| المؤلفون: | Wei Ling, Wan Li Liu, Feng Chen, Weimin Ye, Zhiwei Liu, Yi Xin Zeng, Shang Hang Xie, Su Mei Cao, Xiang Guo, Fang Fang, Qi Hong Huang, Wei Min Cheng, Yuan Long Yu, Biao Hua Wu, Wei Hua Jia, Kuang Rong Wei, Ming Fang Ji, Ming Huang Hong, Xiao Lin, Er Hong Lin, Hao Yuan Mo, You Ye Yang, Qing Liu, Yue Liu |
| المصدر: | American Journal of Epidemiology. 177:242-250 |
| بيانات النشر: | Oxford University Press (OUP), 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | medicine.medical_specialty, medicine.diagnostic_test, biology, Epidemiology, business.industry, Cancer, Physical examination, medicine.disease_cause, medicine.disease, Epstein–Barr virus, Gastroenterology, Serology, Nasopharyngeal carcinoma, Internal medicine, Biopsy, Immunology, medicine, biology.protein, Antibody, business, Mass screening |
| الوصف: | A nasopharyngeal carcinoma (NPC) mass screening trial using a combination of immunoglobulin A antibodies to Epstein-Barr virus capsid antigen and nuclear antigen-1 by enzyme-linked immunosorbent assay in addition to indirect mirror examination in the nasopharynx and/or lymphatic palpation (IMLP) was conducted in southern China. Cantonese aged 30-59 years residing in 2 cities randomly selected by cluster sampling, Sihui and Zhongshan, were invited to participate in this screening from May 2008 through May 2010. Participants were offered fiberoptic endoscopy examination and/or pathologic biopsy if their serologic tests reached our predefined level of high risk or if results from the physical examination indicated possible cancer (i.e., were IMLP positive). A total of 28,688 individuals were voluntarily screened in the initial round. The overall NPC detection rate was 0.14% (41/28,688) with an early diagnosis rate of 68.3% (28/41) during the first year of follow-up. Thirty-eight of 41 cases (92.7%) were detected among the high-risk group, and 7 of 41 cases (17.1%) were detected among the IMLP-positive group. The 2 Epstein-Barr virus serologic tests by enzyme-linked immunosorbent assay could be a feasible alternative for NPC screening in endemic areas. Further follow-up is needed to examine whether screening has an effect on decreasing mortality from NPC in these areas. |
| تدمد: | 1476-6256 0002-9262 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::0e25bd3f829fed31657091fe0d50c366Test https://doi.org/10.1093/aje/kws404Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........0e25bd3f829fed31657091fe0d50c366 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14766256 00029262 |
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