Guillain-Barre Syndrome, Influenzalike Illnesses, and Influenza Vaccination During Seasons With and Without Circulating A/H1N1 Viruses
| العنوان: | Guillain-Barre Syndrome, Influenzalike Illnesses, and Influenza Vaccination During Seasons With and Without Circulating A/H1N1 Viruses |
|---|---|
| المؤلفون: | Lamiae, Grimaldi-Bensouda, Annick, Alpérovitch, Gérard, Besson, Christophe, Vial, Jean-Marie, Cuisset, Caroline, Papeix, Olivier, Lyon-Caen, Jacques, Benichou, Michel, Rossignol, V, Pautot |
| المصدر: | American Journal of Epidemiology. 174:326-335 |
| بيانات النشر: | Oxford University Press (OUP), 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Adult, Male, Pediatrics, medicine.medical_specialty, Adolescent, Epidemiology, Orthomyxoviridae, Guillain-Barre Syndrome, medicine.disease_cause, Disease Outbreaks, Young Adult, Influenza A Virus, H1N1 Subtype, Sex Factors, Risk Factors, Influenza, Human, Confidence Intervals, Odds Ratio, medicine, Influenza A virus, Humans, Family history, Risk factor, Child, Aged, Guillain-Barre syndrome, biology, business.industry, Age Factors, Odds ratio, Middle Aged, medicine.disease, biology.organism_classification, Vaccination, Logistic Models, Influenza Vaccines, Case-Control Studies, Child, Preschool, Immunology, Human mortality from H5N1, Female, France, business |
| الوصف: | The role of influenzalike illnesses and influenza vaccination in the development of Guillain-Barré syndrome (GBS), particularly the role of A/H1N1 epidemics and A/H1N1 vaccination, is debated. Data on all incident GBS cases meeting the Brighton Collaboration criteria that were diagnosed at 25 neurology centers in France were prospectively collected between March 2007 and June 2010, covering 3 influenzavirus seasons, including the 2009-2010 A/H1N1 outbreak. A total of 457 general practitioners provided a registry of patients from which 1,080 controls were matched by age, gender, index date (calendar month), and region to 145 cases. Causal relations were assessed by multivariate case-control analysis with adjustment for risk factors (personal and family history of autoimmune disorders, among others), while matching on age, gender, and calendar time. Influenza (seasonal or A/H1N1) or influenzalike symptoms in the 2 months preceding the index date was associated with GBS, with a matched odds ratio of 2.3 (95% confidence interval (CI): 0.7, 8.2). The difference in the rates of GBS occurring between influenza virus circulation periods and noncirculation periods was highly statistically significant (P = 0.004). Adjusted odds ratios for GBS occurrence within 6 weeks after seasonal and A/H1N1 vaccination were 1.3 (95% CI: 0.4, 4.1) and 0.9 (95% CI: 0.1, 7.6), respectively. Study results confirm that influenza virus is a likely risk factor for GBS. Conversely, no new concerns have arisen regarding influenza vaccination. |
| تدمد: | 1476-6256 0002-9262 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74cc484b7f4158654db4a0de6721ab4cTest https://doi.org/10.1093/aje/kwr072Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....74cc484b7f4158654db4a0de6721ab4c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14766256 00029262 |
|---|