دورية أكاديمية
Significance of expression of ITGA5 and its splice variants in acute myeloid leukemia: a report from the Children's Oncology Group.
| العنوان: | Significance of expression of ITGA5 and its splice variants in acute myeloid leukemia: a report from the Children's Oncology Group. |
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| المؤلفون: | Walter, Roland B, Laszlo, George S, Alonzo, Todd A, Gerbing, Robert B, Levy, Shawn, Fitzgibbon, Matthew P, Gudgeon, Chelsea J, Ries, Rhonda E, Harrington, Kimberly H, Raimondi, Susana C, Hirsch, Betsy A, Gamis, Alan S, W McIntosh, Martin, Meshinchi, Soheil |
| المصدر: | Am J Hematol ; ISSN:1096-8652 ; Volume:88 ; Issue:8 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2013 |
| المجموعة: | PubMed Central (PMC) |
| الوصف: | Acute myeloid leukemia (AML) encompasses a heterogeneous group of diseases, and novel biomarkers for risk refinement and stratification are needed to optimize patient care. To identify novel risk factors, we performed transcriptome sequencing on 68 diagnostic AML samples and identified 2 transcript variants (-E2 and -E2/3) of the α-subunit (ITGA5) of the very late antigen-5 integrin. We then quantified expression of ITGA5 and these splice variants in specimens from participants of the AAML03P1 trial. We found no association between ITGA5 expression and clinical outcome. In contrast, patients with the highest relative expression (Q4) of the -E2/3 ITGA5 splice variant less likely had low-risk disease than Q1-3 patients (21% vs. 38%, P = 0.027). Q4 patients had worse response to chemotherapy with a higher proportion having persistent minimal residual disease (50% vs. 23%, P = 0.003) and inferior overall survival (at 5 years: 48% vs. 67%, P = 0.015); the latter association was limited to low-risk patients (Q4 vs. Q1-3: 56% vs. 85%, P = 0.043) and was not seen in standard-risk (51% vs. 60%, P = 0.340) or high-risk (33% vs. 38%, P = 0.952) patients. Our exploratory studies indicate that transcriptome sequencing is useful for biomarker discovery, as exemplified by the identification of ITGA5 -E2/3 splice variant as potential novel adverse prognostic marker for low-risk AML that, if confirmed, could serve to further risk-stratify this patient subset. |
| نوع الوثيقة: | article in journal/newspaper report |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1002/ajh.23486Test; https://pubmed.ncbi.nlm.nih.gov/23686445Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757130Test/ |
| DOI: | 10.1002/ajh.23486 |
| الإتاحة: | https://doi.org/10.1002/ajh.23486Test https://pubmed.ncbi.nlm.nih.gov/23686445Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757130Test/ |
| حقوق: | Copyright © 2013 Wiley Periodicals, Inc. |
| رقم الانضمام: | edsbas.E2911EB3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/ajh.23486 |
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