التفاصيل البيبلوغرافية
| العنوان: |
Methotrexate and relative risk of dementia amongst patients with rheumatoid arthritis: a multi-national multi-database case-control study. |
| المؤلفون: |
Newby, Danielle, Prieto-Alhambra, Daniel, Duarte-Salles, Talita, Ansell, David, Pedersen, Lars, van der Lei, Johan, Mosseveld, Mees, Rijnbeek, Peter, James, Glen, Alexander, Myriam, Egger, Peter, Podhorna, Jana, Stewart, Robert, Perera, Gayan, Avillach, Paul, Grosdidier, Solène, Lovestone, Simon, Nevado-Holgado, Alejo J. |
| المصدر: |
Alzheimer's Research & Therapy; 4/6/2020, Vol. 12 Issue 1, p1-10, 10p |
| مصطلحات موضوعية: |
RHEUMATOID arthritis, METHOTREXATE, DEMENTIA patients, CASE-control method, ELECTRONIC health records, VASCULAR dementia |
| مصطلحات جغرافية: |
DENMARK, NETHERLANDS |
| مستخلص: |
Background: Inflammatory processes have been shown to play a role in dementia. To understand this role, we selected two anti-inflammatory drugs (methotrexate and sulfasalazine) to study their association with dementia risk. Methods: A retrospective matched case-control study of patients over 50 with rheumatoid arthritis (486 dementia cases and 641 controls) who were identified from electronic health records in the UK, Spain, Denmark and the Netherlands. Conditional logistic regression models were fitted to estimate the risk of dementia. Results: Prior methotrexate use was associated with a lower risk of dementia (OR 0.71, 95% CI 0.52–0.98). Furthermore, methotrexate use with therapy longer than 4 years had the lowest risk of dementia (odds ratio 0.37, 95% CI 0.17–0.79). Sulfasalazine use was not associated with dementia (odds ratio 0.88, 95% CI 0.57–1.37). Conclusions: Further studies are still required to clarify the relationship between prior methotrexate use and duration as well as biological treatments with dementia risk. [ABSTRACT FROM AUTHOR] |
|
Copyright of Alzheimer's Research & Therapy is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder