التفاصيل البيبلوغرافية
| العنوان: |
20‐year depressive symptoms, dementia, and structural neuropathology in older women |
| المؤلفون: |
Petkus, Andrew J., Wang, Xinhui, Younan, Diana, Salminen, Lauren E., Resnick, Susan M., Rapp, Stephen R., Espeland, Mark A., Gatz, Margaret, Widaman, Keith F., Casanova, Ramon, Chui, Helena, Barnard, Ryan T., Gaussoin, Sarah A., Goveas, Joseph S., Hayden, Kathleen M., Henderson, Victor W., Sachs, Bonnie C., Saldana, Santiago, Shadyab, Aladdin H., Shumaker, Sally A., Chen, Jiu‐Chiuan |
| المساهمون: |
Wake Forest University, National Institute on Aging |
| المصدر: |
Alzheimer's & Dementia ; ISSN 1552-5260 1552-5279 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2024 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
INTRODUCTION The course of depressive symptoms and dementia risk is unclear, as are potential structural neuropathological common causes. METHODS Utilizing joint latent class mixture models, we identified longitudinal trajectories of annually assessed depressive symptoms and dementia risk over 21 years in 957 older women (baseline age 72.7 years old) from the Women's Health Initiative Memory Study. In a subsample of 569 women who underwent structural magnetic resonance imaging, we examined whether estimates of cerebrovascular disease and Alzheimer's disease (AD)‐related neurodegeneration were associated with identified trajectories. RESULTS Five trajectories of depressive symptoms and dementia risk were identified. Compared to women with minimal symptoms, women who reported mild and stable and emerging depressive symptoms were at the highest risk of developing dementia and had more cerebrovascular disease and AD‐related neurodegeneration. DISCUSSION There are heterogeneous profiles of depressive symptoms and dementia risk. Common neuropathological factors may contribute to both depression and dementia. Highlights The progression of depressive symptoms and concurrent dementia risk is heterogeneous. Emerging depressive symptoms may be a prodromal symptom of dementia. Cerebrovascular disease and AD are potentially shared neuropathological factors. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1002/alz.13781 |
| الإتاحة: |
https://doi.org/10.1002/alz.13781Test |
| حقوق: |
http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.C31FEF18 |
| قاعدة البيانات: |
BASE |
