Factors associated with severity of occupational asthma with a latency period at diagnosis
| العنوان: | Factors associated with severity of occupational asthma with a latency period at diagnosis |
|---|---|
| المؤلفون: | Dominique Choudat, Jacques Ameille, Alexis Descatha, Jean-Claude Pairon, Robert Garnier, Hélène Leproust |
| المصدر: | Allergy. 62:795-801 |
| بيانات النشر: | Wiley, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | medicine.medical_specialty, Multivariate analysis, business.industry, Immunology, macromolecular substances, medicine.disease, Occupational safety and health, 3. Good health, Occupational medicine, Atopy, 03 medical and health sciences, 0302 clinical medicine, 030228 respiratory system, Internal medicine, Severity of illness, Physical therapy, medicine, Immunology and Allergy, 030212 general & internal medicine, Prospective cohort study, business, Occupational asthma, Asthma |
| الوصف: | BACKGROUND Severity of occupational asthma at diagnosis is an important prognostic factor. The aim of this study was to determine which factors affect the severity of occupational asthma with a latency period at diagnosis. METHODS The study population consisted of 229 consecutive subjects with occupational asthma with a latency period recruited by four occupational health departments and divided into two groups according to the severity of the disease at diagnosis. The moderate-severe (FEV(1) /=70% predicted and PD(20) methacholine >300 microg, n = 128) groups were compared in terms of clinical and demographic parameters. Multivariate analysis using logistic regressions was performed to examine factors associated with asthma severity. RESULTS Duration of symptoms before diagnosis was significantly longer in the moderate-severe group (mean +/- SD: 6.3 +/- 6.8 years vs 3.4 +/- 4.4 years, P < 0.001). Sex ratio, age, atopy, smoking habits, duration of exposure before symptoms, and molecular weight of the causal agent were not significantly different between the two groups. On multivariate analysis, only duration of symptoms before diagnosis was associated with asthma severity (aOR = 1.12, 95% CI 1.05-1.18, P < 0.001). CONCLUSIONS Severity of occupational asthma with a latency period at diagnosis was associated with duration of symptoms before diagnosis, but not with the type of causal agent. This finding emphasizes the need for early diagnosis and avoidance of exposure. |
| تدمد: | 1398-9995 0105-4538 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::6955828077d845a63324337cdc902030Test https://doi.org/10.1111/j.1398-9995.2007.01424.xTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........6955828077d845a63324337cdc902030 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13989995 01054538 |
|---|