المؤلفون: Cait, Alissa¹ (AUTHOR), Wedel, Alexander² (AUTHOR), Arntz, Jeanne L.³ (AUTHOR), Duinkerken, Jacyra³ (AUTHOR), Datye, Swarali³ (AUTHOR), Cait, Jessica⁴ (AUTHOR), Alhasan, Moumen M.³ (AUTHOR), Conrad, Melanie L.^3,5 (AUTHOR) conradml@gmail.com

المصدر: Allergy. Nov2022, Vol. 77 Issue 11, p3233-3248. 16p.

مصطلحات موضوعية: *PRENATAL exposure, *ASTHMA, *ASTHMA in children, *JUVENILE diseases, *ALLERGIC rhinitis

الشركة/الكيان: DEUTSCHE Forschungsgemeinschaft

مستخلص: Antibiotic use during pregnancy may increase the risk for asthma in children. We performed a meta‐analysis assessing prenatal antibiotic exposure and the risk for childhood wheeze or asthma, as well as for diseases associated with the atopic march. A systematic literature search protocol (PROSPERO‐ID: CRD42020191940) was registered and searches were completed using Medline, Proquest, Embase, and the Cochrane central register of controlled trials. Screening for inclusion criteria: published in English, German, French, Dutch, or Arabic, intervention (use of any antibiotic at any time point during pregnancy), and disease (reporting atopic disease incidence in children with a primary outcome of asthma or wheeze), and exclusion criteria: reviews, preclinical data, and descriptive studies, yielded 27 studies. Study quality was assessed using the Newcastle–Ottawa Assessment Scale. Quality of the evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach. Our meta‐analysis demonstrates that antibiotic use during pregnancy is associated with an increased relative risk (RR) of developing wheeze RR 1.51 (95% CI: 1.17–1.94) or asthma RR 1.28 (95% CI 1.22–1.34) during childhood. Assessment of the atopic march in association with asthma or wheeze revealed that antibiotic use during pregnancy also increases the risk for eczema/dermatitis RR 1.28 (95% CI: 1.06–1.53) and allergic rhinitis RR 1.13 (95% CI: 1.02–1.25). One study found an increase in food allergy RR 1.81 (95% CI: 1.11–2.95). Maternal antibiotic use during pregnancy is associated with an increased risk for wheeze or asthma development in children, as well as for diseases involved in the atopic march. There was high heterogeneity in the data, and the certainty of the evidence was determined to be low quality, highlighting the need for more high‐quality studies on this topic. These results have importance for antibiotic stewardship throughout the prenatal period. This work was supported by the Deutsche Forschungsgemeinschaft and the Konrad Adenauer Foundation. [ABSTRACT FROM AUTHOR]

المؤلفون: Thürmann, Loreen¹ (AUTHOR), Herberth, Gunda² (AUTHOR), Seiwert, Bettina³ (AUTHOR), Schlittenbauer, Linda³ (AUTHOR), Rolle‐Kampczyk, Ulrike⁴ (AUTHOR), Röder, Stefan² (AUTHOR), Sack, Ulrich⁵ (AUTHOR), Borte, Michael⁶ (AUTHOR), von Bergen, Martin^4,7 (AUTHOR), Trump, Saskia¹ (AUTHOR), Reemtsma, Thorsten³ (AUTHOR), Lehmann, Irina¹ (AUTHOR) irina.lehmann@charite.de

المصدر: Allergy. Oct2021, Vol. 76 Issue 10, p3122-3132. 11p.

مصطلحات موضوعية: *PRENATAL exposure delayed effects, *AMNIOTIC liquid, *ATOPIC dermatitis, *ASTHMA, *CONSUMER goods, *PHENOTYPES

مستخلص: Background: Parabens, widely used as preservatives in cosmetics, foods, and other consumer products, are suspected of contributing to allergy susceptibility. The detection of parabens in the placenta or amniotic fluid raised concerns about potential health consequences for the child. Recently, an increased asthma risk following prenatal exposure has been reported. Here, we investigated whether prenatal paraben exposure can influence the risk for atopic dermatitis (AD). Methods: 261 mother‐child pairs of the German mother‐child study LINA were included in this analysis. Eight paraben species were quantified in maternal urine obtained at gestational week 34. According to the parental report of physician‐diagnosed AD from age 1 to 8 years, disease onset, and persistence, childhood AD was classified into four different phenotypes. Results: 4.6% (n = 12) and 12.3% (n = 32) of the children were classified as having very early‐onset AD (until age two) either with or without remission, 11.9% (n = 31) as early‐onset (after age two), and 3.1% (n = 8) as childhood‐onset AD (after age six). Exposure to ethylparaben and n‐butylparaben was associated with an increased risk to develop very early‐onset AD without remission (EtP: adj.OR/95% CI:1.44/1.04–2.00,nBuP:adj.OR/95% CI:1.95/1.22–3.12). The effects of both parabens were predominant in children without a history of maternal AD and independent of children's sex. Conclusion: Prenatal EtP or nBuP exposure may increase children's susceptibility for persistent AD with disease onset at very early age. This association was particularly pronounced in children without a history of maternal AD, indicating that children without a genetic predisposition are more susceptible to paraben exposure. [ABSTRACT FROM AUTHOR]

المؤلفون: Yao, Tsung‐Chieh, Huang, Hsin‐Yi, Pan, Wen‐Chi, Wu, Chao‐Yi, Tsai, Shun‐Yu, Hung, Chi‐Yen, Lu, Kun‐Lin, Chang‐Chien, Ju, Tseng, Chih‐Lin, Wu, Chih‐Da, Chen, Yu‐Chen, Huang, Yvonne J., Tsai, Hui‐Ju

المصدر: Allergy; Jul2021, Vol. 76 Issue 7, p2241-2245, 5p

مصطلحات موضوعية: ECZEMA, PARTICULATE matter, TOBACCO smoke pollution, POLLUTION, PRENATAL exposure

مستخلص: Eczema was defined as having physician-diagnosed eczema and presence of eczema in the last 12 months through a modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire provided by parents/guardians of the study participants.7 We applied a distributed lag nonlinear model to examine the exposure-lag-response association of eczema with mean weekly PM SB 2.5 sb estimates using a highly spatial-temporal resolution hybrid kriging/land-use regression model. This study has identified, for the first time, a sensitive window of exposure to PM SB 2.5 sb at gestational weeks 7 to 17 on the risk of developing childhood eczema, which may provide insight into underlying mechanisms. In gestational week 12, the concentration-response relationship indicated that the AOR of childhood eczema was significantly higher than 1.0 at PM SB 2.5 sb concentrations greater than 21.2 g/m SP 3 sp (Figure S3). Atopic eczema (or atopic dermatitis) is a chronic relapsing inflammatory skin disease affecting 15-30% of children worldwide.1 Although previous studies have attempted to link higher prenatal exposure to particulate matter with childhood eczema,2-6 most studies examined particulate matter with an aerodynamic diameter of 10 m or less (PM SB 10 sb ), but not particulate matter with an aerodynamic diameter of 2.5 m or less (PM SB 2.5 sb ), and yielded inconsistent results. [Extracted from the article]

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المؤلفون: Smit, L. A. M.¹, Lenters, V.¹, Høyer, B. B.², Lindh, C. H.³, Pedersen, H. S.⁴, Liermontova, I.⁵, Jönsson, B. A. G.³, Piersma, A. H.⁶, Bonde, J. P.⁷, Toft, G.², Vermeulen, R.¹, Heederik, D.¹

المصدر: Allergy. Jun2015, Vol. 70 Issue 6, p653-660. 8p. 3 Charts.

مصطلحات موضوعية: *ASTHMA in children, *PRENATAL exposure delayed effects, *ECZEMA in children, *POLLUTANTS, *DIETHYLHEXYL phthalate, *MULTIVARIATE analysis, *ASTHMA risk factors

مستخلص: Background Emerging evidence suggests that prenatal or early-life exposures to environmental contaminants may contribute to an increased risk of asthma and allergies in children. We aimed to the explore associations of prenatal exposures to a large set of environmental chemical contaminants with asthma and eczema in school-age children. Methods We studied 1024 mother-child pairs from Greenland and Ukraine from the INUENDO birth cohort. Data were collected by means of an interview-based questionnaire when the children were 5-9 years of age. Questions from the ISAAC study were used to define asthma, eczema, and wheeze. We applied principal components analysis ( PCA) to sixteen contaminants in maternal serum sampled during pregnancy, including perfluoroalkyl substances ( PFASs), metabolites of diethylhexyl ( DEHP) and diisononyl ( Di NP) phthalates, PCB-153, and p,p′- DDE. Scores of five principal components ( PCs) explaining 70% of the variance were included in multiple logistic regression models. Results In a meta-analysis that included both populations, the PC2 score, reflecting exposure to Di NP, was negatively associated with current eczema ( OR 0.71, 95% CI 0.52-0.96). Other associations were not consistent between the two populations. In Ukrainian children, the PC3 score ( DEHP) was positively associated with current wheeze (adjusted OR 1.56, 95% CI 1.03-2.37), whereas the PC5 score, dominated by perfluorooctanoic acid ( PFOA), was inversely associated with current wheeze ( OR 0.64, 0.41-0.99). In Greenlandic children, a negative association of PC4 (organochlorines) with ever eczema ( OR 0.78, 0.61-0.99) was found. Conclusions We found limited evidence to support a link between prenatal exposure to environmental chemical contaminants and childhood asthma and eczema. [ABSTRACT FROM AUTHOR]

المؤلفون: Alexander Wedel, Alissa Cait, William W. Mohn, Elisa B. Sodemann, Stefan Bereswill, Ali Önder Yildirim, Robert Klopfleisch, Michael Blaut, Markus M. Heimesaat, Moumen M. Alhasan, Thomas M. Conlon, Melanie L. Conrad

المصدر: Allergy 75, 1979-1990 (2020)

مصطلحات موضوعية: 0301 basic medicine, Ovalbumin, medicine.drug_class, Offspring, Immunology, Antibiotics, microbiome, Physiology, antibiotics, Mice, 03 medical and health sciences, 0302 clinical medicine, ddc:150, Hypersensitivity, medicine, Animals, Humans, Immunology and Allergy, Weaning, Microbiome, Asthma, Pregnancy, business.industry, Short-chain Fatty Acid, asthma, medicine.disease, Anti-Bacterial Agents, 030104 developmental biology, 030228 respiratory system, Prenatal Exposure Delayed Effects, Gestation, Vancomycin, Female, pregnancy, short-chain fatty acid, business, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit, medicine.drug

الوصف: Background The use of antibiotics during pregnancy is associated with increased allergic asthma risk in the offspring, and given that approximately 25% of pregnant women are prescribed antibiotics, it is important to understand the mechanisms contributing to this phenomenon. Currently, there are no studies that directly test this association experimentally. Our objective was to develop a mouse model in which antibiotic treatment during pregnancy results in increased offspring asthma susceptibility. Methods Pregnant mice were treated daily from gestation day 8-17 with an oral solution of the antibiotic vancomycin, and three concentrations were tested. At weaning, offspring were subjected to an adjuvant-free experimental asthma protocol using ovalbumin as an allergen. The composition of the gut microbiome was determined in mothers and offspring with samples collected from five different time points; short-chain fatty acids were also analyzed in allergic offspring. Results We found that maternal antibiotic treatment during pregnancy was associated with increased offspring asthma severity in a dose-dependent manner. Furthermore, maternal vancomycin treatment during pregnancy caused marked changes in the gut microbiome composition in both mothers and pups at several different time points. The increased asthma severity and intestinal microbiome changes in pups were also associated with significantly decreased cecal short-chain fatty acid concentrations. Conclusion Consistent with the "Developmental Origins Hypothesis," our results confirm that exposure to antibiotics during pregnancy shapes the neonatal intestinal environment and increases offspring allergic lung inflammation.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8577dc428eedb5e4f4e553c81b32ab2Test
https://doi.org/10.1111/all.14234Test

المؤلفون: Yu Chen Chen, Yvonne J. Huang, Shun Yu Tsai, Chih Lin Tseng, Hsin Yi Huang, Tsung Chieh Yao, Chao-Yi Wu, Chi Yen Hung, Kun Lin Lu, Chih Da Wu, Hui Ju Tsai, Ju Chang-Chien, Wen Chi Pan

المصدر: Allergy

مصطلحات موضوعية: Pollution, Air Pollutants, Fine particulate, business.industry, media_common.quotation_subject, Immunology, Eczema, Environmental Exposure, Article, Maternal Exposure, Pregnancy, Environmental health, Air Pollution, Prenatal Exposure Delayed Effects, Immunology and Allergy, Medicine, Humans, Female, Particulate Matter, business, Child, Prenatal exposure, media_common

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3364931d3b79125115ce06c71db9641bTest
https://pubmed.ncbi.nlm.nih.gov/33432626Test

المؤلفون: Hyun-Ju Cho, So-Yeon Lee, Yeongho Kim, Hwan-Cheol Kim, Jisun Yoon, Jong Han Leem, Eun Lee, Young-Ho Jung, Ju Hee Seo, Hyo Bin Kim, Soo-Jong Hong, Song-I Yang, Sungsu Jung, Hyeok Kwon, Ho-Jang Kwon, Hyeon-Jong Yang

المصدر: Allergy. 74:675-684

مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_specialty, Via airway, Immunology, Airway hyperresponsiveness, New diagnosis, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Surveys and Questionnaires, Internal medicine, Republic of Korea, Respiratory Hypersensitivity, medicine, Humans, Immunology and Allergy, Child, Asthma, business.industry, Infant, medicine.disease, respiratory tract diseases, 030104 developmental biology, 030228 respiratory system, Bronchial hyperresponsiveness, In utero, Pregnancy Trimester, Second, Prenatal Exposure Delayed Effects, Female, Particulate Matter, Methacholine, business, medicine.drug

الوصف: Background The most relevant time of PM10 exposure to affect airway hyperresponsiveness (AHR) and new development of asthma in school-aged children is unclear. The aims of this study were to investigate the most critical time of PM10 exposure to affect AHR and new diagnosis of asthma from AHR in school-aged children. Methods Elementary schoolchildren (n = 3570) have been enrolled in a nationwide prospective 4-year follow-up survey in Korea from 2005 to 2006. Individual annual PM10 exposure was estimated by using an ordinary kriging method from the prenatal period to 7 years of age. AHR at 7 years was defined by a methacholine PC20 ≤8 mg/mL. Results PM10 exposure during pregnancy and at 1 year of age showed significant effects on AHR (aOR: 1.694, 95% CI: 1.298-2.209; and aOR: 1.750, 95% CI: 1.343-2.282, respectively). PM10 exposure during pregnancy was associated with the risk of a new diagnosis of asthma (aOR: 2.056, 95% CI: 1.240-3.409), with the highest risk in children with AHR at age 7 (aOR: 6.080, 95% CI: 2.150-17.195). PM10 exposure in the second trimester was associated with the highest risk of a new diagnosis of asthma in children with AHR at age 7 (aOR: 4.136, 95% CI: 1.657-10.326). Conclusions Prenatal PM10 exposure in the second trimester is associated with an increased risk of a new diagnosis of asthma in school-aged children with AHR at 7 years. This study suggests that PM10 exposure during a specific trimester in utero may affect the onset of childhood asthma via AHR.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f335ab9e90a93d61d3b868c64883293eTest
https://doi.org/10.1111/all.13649Test

المؤلفون: Charlotta Flodström, Gunnar Lilja, Anna Nopp, Inger Kull, Anna Bergström

المصدر: Allergy. 74:402-405

مصطلحات موضوعية: Pediatrics, medicine.medical_specialty, Time Factors, Offspring, Eggs, Immunology, MEDLINE, Disease, Pregnancy, Intervention (counseling), Hypersensitivity, medicine, Animals, Humans, Immunology and Allergy, business.industry, Follow up studies, medicine.disease, Diet, Milk, Prenatal Exposure Delayed Effects, Maternal Exposure, Population Surveillance, Cattle, Female, business, Follow-Up Studies

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c1f0c2791eb526491db1b14a3cf6264Test
https://doi.org/10.1111/all.13621Test

المؤلفون: Reimar W. Thomsen, Jørn Olsen, Trine Munk-Olsen, Shyamali C. Dharmage, Jiong Li, Esben Agerbo, Xiaoqin Liu

المصدر: Liu, X, Agerbo, E, Li, J, Dharmage, S C, Thomsen, R W, Olsen, J & Munk-Olsen, T 2018, ' Maternal pregestational or gestational diabetes and childhood wheezing : A population-based cohort study ', Allergy: European Journal of Allergy and Clinical Immunology, vol. 73, no. 11, pp. 2247-2250 . https://doi.org/10.1111/all.13551Test

مصطلحات موضوعية: Adult, Pediatrics, medicine.medical_specialty, Denmark, Immunology, MEDLINE, Cohort Studies, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Diabetes mellitus, Prevalence, medicine, Humans, Immunology and Allergy, Registries, 030212 general & internal medicine, Respiratory sounds, Young adult, Respiratory Sounds, medicine.diagnostic_test, business.industry, Middle Aged, medicine.disease, Gestational diabetes, Diabetes, Gestational, 030228 respiratory system, Maternal Exposure, Population Surveillance, Prenatal Exposure Delayed Effects, Gestation, Female, business, Cohort study

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::906e926e8201b92747985924bee75ccbTest
https://doi.org/10.1111/all.13551Test

المؤلفون: Lockett, G. A., Soto-Ramirez, N., Ray, M. A., Everson, T. M., Xu, C-J., Patil, V. K., Terry, W., Kaushal, A., Rezwan, F. I., Ewart, S. L., Gehring, U., Postma, D. S., Koppelman, G. H., Arshad, S. H., Zhang, H., Karmaus, W., Holloway, J. W., LS IRAS EEPI ME (Milieu epidemiologie), Sub Medicinal Chemistry & Chemical biol., dIRAS RA-2

المساهمون: Groningen Research Institute for Asthma and COPD (GRIAC), LS IRAS EEPI ME (Milieu epidemiologie), Sub Medicinal Chemistry & Chemical biol., dIRAS RA-2

المصدر: Allergy, 71(9), 1314-1324. Wiley-Blackwell
Allergy: European Journal of Allergy and Clinical Immunology, 71(9), 1314. Blackwell Publishing Ltd

مصطلحات موضوعية: Male, 0301 basic medicine, Allergy, 0302 clinical medicine, Pregnancy, Immunology and Allergy, Child, RISK, DNA methylation, Methylation, epigenome-wide association study, 3. Good health, PREVALENCE, Maternal Exposure, Child, Preschool, Prenatal Exposure Delayed Effects, Cohort, INFANCY, Female, Disease Susceptibility, Seasons, 450K array, Cohort study, PACKAGE, Adolescent, Season of birth, DISORDERS, Immunology, Biology, Article, MECHANISMS, 03 medical and health sciences, Hypersensitivity, medicine, Humans, COHORT, Epigenetics, EARLY-CHILDHOOD, POLYMORPHISMS, epigenetics, season of birth, Infant, Newborn, Infant, Reproducibility of Results, Immunoglobulin E, medicine.disease, 030104 developmental biology, 030228 respiratory system, ASTHMA, CpG Islands

الوصف: BackgroundSeason of birth influences allergy risk; however, the biological mechanisms underlying this observation are unclear. The environment affects DNA methylation, with potentially long-lasting effects on gene expression and disease. This study examined whether DNA methylation could underlie the association between season of birth and allergy.MethodsIn a subset of 18-year-old participants from the Isle of Wight (IoW) birth cohort (n = 367), the risks of birth season on allergic outcomes were estimated. Whole blood epigenome-wide DNA methylation was measured, and season-associated CpGs detected using a training-and-testing-based technique. Validation method examined the 8-year-old Prevention and Incidence of Asthma and Mite Allergy (PIAMA) cohort. The relationships between DNA methylation, season of birth and allergy were examined. CpGs were analysed in IoW third-generation cohort newborns.ResultsAutumn birth increased risk of eczema, relative to spring birth. Methylation at 92 CpGs showed association with season of birth in the epigenome-wide association study. In validation, significantly more CpGs had the same directionality than expected by chance, and four were statistically significant. Season-associated methylation was enriched among networks relating to development, the cell cycle and apoptosis. Twenty CpGs were nominally associated with allergic outcomes. Two CpGs were marginally on the causal pathway to allergy. Season-associated methylation was largely absent in newborns, suggesting it arises post-natally.ConclusionsThis study demonstrates that DNA methylation in adulthood is associated with season of birth, supporting the hypothesis that DNA methylation could mechanistically underlie the effect of season of birth on allergy, although other mechanisms are also likely to be involved.

وصف الملف: text; application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bff5c7379b5e6f72b165283880a51c8dTest
https://doi.org/10.1111/all.12882Test