Fexofenadine reduces nasal congestion in perennial allergic rhinitis
| العنوان: | Fexofenadine reduces nasal congestion in perennial allergic rhinitis |
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| المؤلفون: | Giorgio Ciprandi, C. Mondino, Cristina Cosentino, Manlio Milanese, Giorgio Walter Canonica |
| المصدر: | Allergy. 56:1068-1070 |
| بيانات النشر: | Wiley, 2001. |
| سنة النشر: | 2001 |
| مصطلحات موضوعية: | Adult, Male, Allergy, medicine.medical_specialty, Rhinitis, Allergic, Perennial, Randomization, Adolescent, Dose, Immunology, Pilot Projects, Nasal congestion, Placebo, Sneezing, Gastroenterology, law.invention, Double-Blind Method, Randomized controlled trial, law, Internal medicine, medicine, Animals, Humans, Immunology and Allergy, Mites, Fexofenadine, Dose-Response Relationship, Drug, business.industry, Therapeutic effect, Middle Aged, medicine.disease, Nasal Mucosa, Treatment Outcome, Anesthesia, Histamine H1 Antagonists, Female, Terfenadine, medicine.symptom, business, medicine.drug |
| الوصف: | Background: Nasal congestion is the predominant symptom in perennial allergic rhinitis (PAR), and it seems to be mainly related to the late-phase inflammatory events. The present pilot study aimed to evaluate the therapeutic effect exerted by fexofenadine in patients with PAR due to mite allergy. Methods: This study was a parallel, double-blind, randomized, three-arm (1:1:1), placebo-controlled study. Thirty-one subjects with PAR were enrolled and received double-blind medication: fexofenadine 120 or 180 mg, or placebo, once a day for 28 days. Results: The total symptom score was reduced by fexofenadine (both dosages) at V2 (P=0.007), whereas placebo did not modify it. Nasal congestion decreased after 1 week of treatment with fexofenadine 120 (P=0.027) and 180 (P=0.01), but not with placebo (P=NS). At V3, fexofenadine (both dosages) significantly reduced nasal congestion (P=0.011 and P=0.007, respectively), by placebo did not show any significant effect. Conclusions: This pilot study represents the first evidence of the efficacy of fexofenadine in PAR, and also the control of the nasal congestion. We suggest performing larger trials to confirm these preliminary findings. |
| تدمد: | 1398-9995 0105-4538 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e111f20764f908ee5489d9478cf92f4aTest https://doi.org/10.1034/j.1398-9995.2001.00191.xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....e111f20764f908ee5489d9478cf92f4a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13989995 01054538 |
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