التفاصيل البيبلوغرافية
| العنوان: |
Systematic review and meta-analysis: enhanced efficacy of proton-pump inhibitor therapy for peptic ulcer bleeding in Asia– a. |
| المؤلفون: |
Leontiadis, G. I.1 (AUTHOR), Sharma, V. K.2 (AUTHOR), Howden, C. W.3 (AUTHOR) |
| المصدر: |
Alimentary Pharmacology & Therapeutics. May2005, Vol. 21 Issue 9, p1055-1061. 7p. |
| مصطلحات موضوعية: |
*PROTON pump inhibitors, *ENZYME inhibitors, *ULCERS, *HEMORRHAGE, *CLINICAL trials, *THERAPEUTICS, *MORTALITY, *PHARMACODYNAMICS |
| مستخلص: |
: Proton-pump inhibitors reduce re-bleeding rates after ulcer bleeding. However, there is significant heterogeneity among different randomized-controlled trials.: To see whether proton-pump inhibitors for ulcer bleeding produced different clinical outcomes in different geographical locations.: This was apost hocanalysis of our Cochrane Collaboration systematic review and meta-analysis of proton-pump inhibitor therapy for ulcer bleeding. Sixteen randomized-controlled trials conducted in Europe and North America were pooled and re-analysed separately from seven conducted in Asia. We calculated pooled rates for 30-day all-cause mortality, re-bleeding and surgical intervention and derived odds ratios and numbers needed to treat with 95% confidence intervals.: There was no significant heterogeneity for any outcome. Reduced all-cause mortality was seen in the Asian randomized-controlled trials (odds ratios = 0.35; 95% confidence interval: 0.16–0.74; number needed to treat = 33), but not in the others (odds ratios = 1.36; 95% confidence interval: 0.94–1.96; number needed to treat– incalculable). There were significant reductions in re-bleeding and surgery in both sets of randomized-controlled trials, but the effects were quantitatively greater in Asia.: Proton-pump inhibitor therapy for ulcer bleeding has been more efficacious in Asia than elsewhere. This may be because of an enhanced pharmacodynamic effect of proton-pump inhibitors in Asian patients. [ABSTRACT FROM AUTHOR] |
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