التفاصيل البيبلوغرافية
| العنوان: |
Long-Term Mortality of Patients with an Alcohol-Related Wernicke–Korsakoff Syndrome. |
| المؤلفون: |
Sanvisens, Arantza, Zuluaga, Paola, Fuster, Daniel, Rivas, Inmaculada, Tor, Jordi, Marcos, Miguel, Chamorro, Antonio J., Muga, Roberto |
| المصدر: |
Alcohol & Alcoholism. Supplement; Jul2017, Vol. 52 Issue 4, p466-471, 6p, 1 Diagram, 3 Charts, 1 Graph |
| مصطلحات موضوعية: |
VITAMIN B1 deficiency, BACTERIAL diseases, CONFIDENCE intervals, CAUSES of death, HOSPITAL admission & discharge, LONGITUDINAL method, PATIENTS, KORSAKOFF'S syndrome, SURVIVAL, TUMORS, COMORBIDITY, TREATMENT effectiveness, WERNICKE'S encephalopathy, RETROSPECTIVE studies, EARLY diagnosis, TERTIARY care, PROGNOSIS, DIAGNOSIS, THERAPEUTICS |
| مستخلص: |
Aims To characterize a series of contemporary patients with alcohol-related Wernicke's encephalopathy (WE) or Korsakoff's syndrome (KS) and to update the current prognosis of disease. Methods Retrospective and prospective study of patients diagnosed with an alcohol-related WE or KS between 2002 and 2011 in a tertiary hospital. Socio-demographic, alcohol use characteristics, signs and symptoms, co-morbidity and blood parameters were obtained at admission. Patients were followed up until 2013 and causes of death were ascertained through the review of charts. Results Sixty-one patients were included (51 with WE and 10 with KS). Among patients with WE, 78% were men and age at diagnosis was 57 years (interquartile range (IQR): 49–66). Twenty-three percent fulfilled the classic WE triad. Regarding Caine's criteria for WE, 70.6% presented with at least two out of four signs or symptoms. Median follow-up of patients with WE syndrome was 5.3 years (IQR: 2.6–8.8), the cumulated mortality was 45% and death rate of 7.4 × 100 person-years (95% confidence interval (CI): 4.8–10.9). Overall, 50% of patients would be expected to die within 8 years of WE episode and main causes of death included serious bacterial infections (44.5%) and cancer (33.3%). Conclusions Survival of patients with an alcohol-related Wernicke–Korsakoff syndrome is poor; pursuing treatment of alcohol use disorder and early diagnosis of thiamine deficiency is a priority for improving clinical outcomes. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
