Low prevalence of transmitted HIV type 1 drug resistance among antiretroviral-naive adults in a rural HIV clinic in Kenya
| العنوان: | Low prevalence of transmitted HIV type 1 drug resistance among antiretroviral-naive adults in a rural HIV clinic in Kenya |
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| المؤلفون: | Clare A. Obonyo, Tobias F. Rinke de Wit, Amin S. Hassan, Shalton M. Mwaringa, James A. Berkley, Patricia A. Cane, Helen M. Nabwera, Eduard J. Sanders |
| المساهمون: | Other departments, Global Health, Infectious diseases |
| المصدر: | AIDS research and human retroviruses, 29(1), 129-135. Mary Ann Liebert Inc. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Adult, Male, Rural Population, medicine.medical_specialty, Cross-sectional study, Anti-HIV Agents, Epidemiology, Immunology, Population, Molecular Sequence Data, Human immunodeficiency virus (HIV), HIV Infections, Drug resistance, medicine.disease_cause, Virus, Cohort Studies, Virology, Internal medicine, Drug Resistance, Viral, medicine, Prevalence, Humans, education, education.field_of_study, business.industry, virus diseases, Kenya, Reverse transcriptase, Infectious Diseases, Cross-Sectional Studies, HIV-1, Female, Rural area, business, Cohort study |
| الوصف: | Low levels of HIV-1 transmitted drug resistance (TDR) have previously been reported from many parts of sub-Saharan Africa (sSA). However, recent data, mostly from urban settings, suggest an increase in the prevalence of HIV-1 TDR. Our objective was to determine the prevalence of TDR mutations among HIV-1-infected, antiretroviral (ARV)-naive adults enrolling for care in a rural HIV clinic in Kenya. Two cross-sectional studies were carried out between July 2008 and June 2010. Plasma samples from ARV-naive adults (>15 years old) at the time of registering for care after HIV diagnosis and before starting ARVs were used. A portion of the pol subgenomic region of the virus containing the protease and part of the reverse transcriptase genes was amplified and sequenced. TDR mutations were identified and interpreted using the Stanford HIV drug resistance database and the WHO list for surveillance of drug resistance strains. Overall, samples from 182 ARV-naive adults [ mean age (95% CI): 34.9 (33.3-36.4) years] were successfully amplified and sequenced. Two TDR mutations to nucleoside reverse transcriptase inhibitors [n = 1 (T215D)] and protease inhibitors [n = 1 (M46L)] were identified, giving an overall TDR prevalence of 1.1% (95% CI: 0.1-3.9). Despite reports of an increase in the prevalence of HIV-1 TDR in some urban settings in sSA, we report a prevalence of HIV-1 TDR of less than 5% at a rural HIV clinic in coastal Kenya. Continued broader surveillance is needed to monitor the extent of TDR in sSA |
| اللغة: | English |
| تدمد: | 1931-8405 0889-2229 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deca6641b37149400a662a85d13ec63aTest http://ora.ox.ac.uk/objects/uuid:924363fc-98d6-4221-ac89-b693e1b859feTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....deca6641b37149400a662a85d13ec63a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19318405 08892229 |
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