التفاصيل البيبلوغرافية
| العنوان: |
Effects of Tuberculosis on the Kinetics of CD4+ T Cell Count Among HIV-infected Patients Who Initiated Antiretroviral Therapy Early After Tuberculosis Treatment. |
| المؤلفون: |
Nam Su Ku, Jin Ok Oh, So Youn Shin, Sun Bean Kim, Hye-won Kim, Su Jin Jeong, Sang Hoon Han, Young Goo Song, June Myung Kim, Jun Yong Choi |
| المصدر: |
AIDS Research & Human Retroviruses; Feb2013, Vol. 29 Issue 2, p226-230, 5p |
| مستخلص: |
The effects of tuberculosis (TB) on the kinetics of CD4+ T cells among HIV-infected individuals with early combination antiretroviral therapy (cART) after TB therapy initiation are poorly characterized. We conducted a case-control study with 15 HIV-TB-coinfected patients who initiated TB treatment and early cART, and 30 controls without TB who had similar CD4+ T cell counts and viral loads at the time of starting cART. We compared the rate of CD4+ T cell increase for 5 years after cART. The time to CD4+ T cell increase >250 cells/mm3 was significantly slower in HIV-TB-coinfected patients (p = 0.015, by log rank test). HIV-TB-coin-fected patients had significantly lower median CD4+ T cell counts at 5 years after cART (p = 0.048). The dif-ference in CD4+ T cell increase was observed only during the first 6 months after cART initiation (p = 0.002). These data suggest that TB slows the rate of CD4+ T cell recovery at an early period after cART. The effects of TB on the long-term immunity of HIV-infected patients should be further evaluated. [ABSTRACT FROM AUTHOR] |
|
Copyright of AIDS Research & Human Retroviruses is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Supplemental Index |
