التفاصيل البيبلوغرافية
| العنوان: |
Weight and Body Mass Index Change After Switching to Integrase Inhibitors or Tenofovir Alafenamide Among Women Living with HIV. |
| المؤلفون: |
Lahiri, Cecile D., Xu, Yanxun, Wang, Kunbo, Alvarez, Jessica A., Sheth, Anandi N., O'Halloran, Jane, Spence, Amanda B., Tien, Phyllis, Gustafson, Deborah R., Milam, Joel, Fischl, Margaret A., Konkle-Parker, Deborah, Adimora, Adaora A., Sharma, Anjali, Weber, Kathleen M., Ofotokun, Igho, Rubin, Leah H. |
| المصدر: |
AIDS Research & Human Retroviruses; Jun2021, Vol. 37 Issue 6, p461-467, 7p |
| مستخلص: |
Weight and body mass index (BMI) change was assessed among women after switch to integrase inhibitors (INSTIs) and/or tenofovir alafenamide (TAF). From 2006 to 2019, 1,458 women living with HIV enrolled in the Women's Interagency HIV Study and on antiretroviral therapy (ART) with ≥1 study visit before and after switching to INSTIs and/or TAF were included. Weight and BMI were compared pre- and postswitch to INSTI (by class and type) and/or TAF using multivariable linear mixed effects models; all models were also stratified by preswitch presence or absence of obesity (BMI ≥30 vs. <30 kg/m2). Mean age preswitch was 47 ± 6 years, 64% were black, mean CD4 = 475 ± 201 cells/mm3, 56% had HIV RNA <200 copies/mL, 36% switched to TAF but not INSTI, 60% to INSTI but not TAF, and 3.5% to TAF+INSTI. Time from pre- to postswitch was 12.8 ± 11.8 months. The INSTI-only group but not TAF groups had small but significant increases in weight and BMI: mean 79.2–80.6 kg and 30.2–30.7 kg/m2, p's < .001, respectively, with congruent findings by INSTI type (p's ≤ .01). In stratified (preswitch BMI) analyses, only nonobese subgroups experienced increases in weight and BMI across all ART treatment groups (p's < .05). Significant, although small-to-medium, increases in weight and BMI occurred among nonobese women who switched to INSTIs and/or TAF over short follow-up. Given long-term health consequences of obesity particularly as a low-grade inflammatory condition, identifying women at highest risk of ART-associated weight gain is imperative. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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