التفاصيل البيبلوغرافية
| العنوان: |
NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast. |
| المؤلفون: |
Jiménez-Hidalgo, María, Santos-Ocaña, Carlos, Padilla, Sergio, Villalba, José M., López-Lluch, Guillermo, Martín-Montalvo, Alejandro, Minor, Robin K., Sinclair, David A., de Cabo, Rafael, Navas, Plácido |
| المصدر: |
Aging Cell; Apr2009, Vol. 8 Issue 2, p140-151, 12p, 2 Diagrams, 1 Chart, 5 Graphs |
| مصطلحات موضوعية: |
CELL membranes, UBIQUINONES, LOW-calorie diet, SACCHAROMYCES cerevisiae, YEAST, METABOLISM |
| مستخلص: |
The activity and expression of plasma membrane NADH coenzyme Q reductase is increased by calorie restriction (CR) in rodents. Although this effect is well-established and is necessary for CR's ability to delay aging, the mechanism is unknown. Here we show that the Saccharomyces cerevisiae homolog, NADH-Coenzyme Q reductase 1 (NQR1), resides at the plasma membrane and when overexpressed extends both replicative and chronological lifespan. We show that NQR1 extends replicative lifespan in a SIR2-dependent manner by shifting cells towards respiratory metabolism. Chronological lifespan extension, in contrast, occurs via an SIR2-independent decrease in ethanol production. We conclude that NQR1 is a key mediator of lifespan extension by CR through its effects on yeast metabolism and discuss how these findings could suggest a function for this protein in lifespan extension in mammals. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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