التفاصيل البيبلوغرافية
| العنوان: |
Transcriptomics age acceleration in prolonged treated HIV infection. |
| المؤلفون: |
Mikaeloff, Flora1 (AUTHOR) flora.mikaeloff@ki.se, Gelpi, Marco2 (AUTHOR), Escos, Alejandra1 (AUTHOR), Knudsen, Andreas D.2 (AUTHOR), Høgh, Julie2 (AUTHOR), Benfield, Thomas3 (AUTHOR), de Magalhães, João Pedro4 (AUTHOR), Nielsen, Susanne D.2 (AUTHOR), Neogi, Ujjwal1 (AUTHOR) ujjwal.neogi@ki.se |
| المصدر: |
Aging Cell. Oct2023, Vol. 22 Issue 10, p1-6. 6p. |
| مصطلحات موضوعية: |
*HIV infections, *ANTIGEN processing, *OXIDATIVE phosphorylation, *HIV-positive persons, *ANTIRETROVIRAL agents, *RETINOIC acid receptors, *CYTOKINE receptors |
| مستخلص: |
Biological aging in people with HIV (PWH) with prolonged successful antiretroviral therapy (ART) is convoluted and poorly defined. Here, we aimed to investigate the transcriptomics age estimator (TAE) in a cohort of 178 PWH on prolonged successful ART with immune reconstitution and viral suppression from the Copenhagen Comorbidity (COCOMO) cohort. We also used 143 clinical, demographical, and lifestyle factors to identify the confounders potentially responsible or associated with age acceleration. Among the PWH, 43% had an accelerated aging process (AAP), and 21% had decelerated aging process (DAP). DAP is linked with older age, European ancestry, and higher use of tenofovir disoproxil/alafenamide fumarate. A directionally class‐based gene set enrichment analysis identified the upregulation of inflammatory pathways (e.g., cytokine and Retinoic acid‐inducible gene I (RIG‐I)‐like receptor signaling pathways) and immune response like T‐cell receptor signaling, antigen processing, and presentation in AAP and the downregulation of metabolic processes like oxidative phosphorylation, pyruvate metabolism. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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