Recombinant interleukin-1 and tumor necrosis factor induce neutrophil migration 'in vivo' by indirect mechanisms
| العنوان: | Recombinant interleukin-1 and tumor necrosis factor induce neutrophil migration 'in vivo' by indirect mechanisms |
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| المؤلفون: | Stephen Poole, S. H. Ferreira, Fernando Q. Cunha, Lúcia Helena Faccioli, G E P Souza |
| المصدر: | Agents and Actions. 30:344-349 |
| بيانات النشر: | Springer Science and Business Media LLC, 1990. |
| سنة النشر: | 1990 |
| مصطلحات موضوعية: | Lipopolysaccharides, Male, medicine.medical_specialty, Neutrophils, Immunology, Recombinant Interleukin, Toxicology, law.invention, Recombinant tumor necrosis factor, In vivo, law, Internal medicine, medicine, Animals, Macrophage, Pharmacology (medical), Pharmacology, Chemotactic Factors, Tumor Necrosis Factor-alpha, Chemistry, Macrophages, Interleukin-8, Rats, Inbred Strains, Chemotaxis, Molecular biology, Recombinant Proteins, In vitro, Rats, Chemotaxis, Leukocyte, Endocrinology, Cell Migration Inhibition, Recombinant DNA, Tumor necrosis factor alpha, Interleukin-1 |
| الوصف: | The alpha and beta forms of recombinant interleukin-1 (IL-1 alpha and IL-1 beta) and of recombinant Tumor Necrosis Factor (TNF alpha and TNF beta) induced dose-dependent neutrophil migration into rat peritoneal cavities. Migration induced by both IL-1s showed a bell-shaped dose-response curve and IL-1 beta was 3-fold more potent than IL-1 alpha. Pretreatment of the animals with dexamethasone or depletion of the peritoneal macrophage population, abolished the neutrophil migration induced by the four cytokines. "In vitro" stimulation of macrophage monolayers with IL-1 beta and the TNFs released a factor into the supernatant which, unlike these cytokines, induced neutrophil migration in dexamethasone pretreated animals. These results suggest that the neutrophil migration induced by IL-1 alpha, IL-1 beta, TNF alpha and TNF beta is not due to a direct effect on neutrophils, but occurs via the release of a chemotactic factor(s) from resident macrophages. |
| تدمد: | 1420-908X 0065-4299 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da80368ae1b9cf28922130d88d98de32Test https://doi.org/10.1007/bf01966298Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....da80368ae1b9cf28922130d88d98de32 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1420908X 00654299 |
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