Chemical changes in aging Drosophila melanogaster
| العنوان: | Chemical changes in aging Drosophila melanogaster |
|---|---|
| المؤلفون: | Richard G. A. Faragher, Elizabeth L. Ostler, Declan P. Naughton, Aamira Iqbal, Linda Partridge, Matthew D.W. Piper |
| المصدر: | Age (Dordr) |
| بيانات النشر: | Springer Science and Business Media LLC, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Glycation End Products, Advanced, Male, Aging, Magnetic Resonance Spectroscopy, media_common.quotation_subject, Article, Oxidative damage, Toxicology, Imaging, Three-Dimensional, Melanogaster, Animals, Fluorometry, Drosophila, Caenorhabditis elegans, Caloric Restriction, media_common, Normal conditions, biology, Life span, Longevity, General Medicine, biology.organism_classification, Oxidative Stress, Drosophila melanogaster, Larva, Biophysics, Female, Geriatrics and Gerontology |
| الوصف: | The "Green Theory" of aging proposes that organismal lifespan is limited by the failure to repair molecular damage generated by a broad range of metabolic processes. Two specific predictions arise from this: (1) that these processes will produce a wide variety of stable but dysfunctional compounds that increase in concentration with age, and (2) that organisms maintained under conditions that extend lifespan will display a reduced rate of accumulation of such "molecular rubbish". To test these predictions, novel analytical techniques were developed to investigate the accumulation of damaged compounds in Drosophila melanogaster. Simple preparative techniques were developed to produce digests of whole D. melanogaster for use in three-dimensional (3D) fluorimetry and 1H NMR spectrometry. Cohorts of Drosophila maintained under normal conditions showed an age-related increase in signals consistent with damage whereas those maintained under conditions of low temperature and dietary restriction did not. 1H NMR revealed distinct age-associated spectral changes that will facilitate the identification of novel compounds that both increase and decrease during aging in this species. These findings are consistent with the predictions of the "Green Theory". |
| تدمد: | 1574-4647 0161-9152 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95862f3078513be2386c31dfef619272Test https://doi.org/10.1007/s11357-009-9105-4Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....95862f3078513be2386c31dfef619272 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15744647 01619152 |
|---|