Biomarkers of oxidative stress are associated with frailty: the Framingham Offspring Study
| العنوان: | Biomarkers of oxidative stress are associated with frailty: the Framingham Offspring Study |
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| المؤلفون: | Na Wang, Asya Lyass, Joanne M. Murabito, Joseph M. Massaro, Christine K. Liu, Ralph B. D'Agostino, Emelia J. Benjamin, Martin G. Larson |
| المصدر: | AGE. 38 |
| بيانات النشر: | Springer Science and Business Media LLC, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Oncology, Aging, medicine.medical_specialty, Time Factors, Offspring, Frail Elderly, Enzyme-Linked Immunosorbent Assay, 030204 cardiovascular system & hematology, medicine.disease_cause, Article, Body Mass Index, 03 medical and health sciences, 0302 clinical medicine, Osteoprotegerin, Nephelometry and Turbidimetry, Risk Factors, Internal medicine, Odds Ratio, medicine, Humans, Prospective Studies, Aged, Framingham Risk Score, business.industry, Incidence, General Medicine, Odds ratio, Stepwise regression, United States, Oxidative Stress, Cross-Sectional Studies, 030104 developmental biology, Endocrinology, Cardiovascular Diseases, Biomarker (medicine), Female, Geriatrics and Gerontology, business, Body mass index, Biomarkers, Oxidative stress, Follow-Up Studies |
| الوصف: | Cardiovascular disease and frailty frequently occur together. Both are associated with inflammation, which may be partially triggered by oxidative stress, especially in cardiovascular disease. We investigated whether inflammatory and oxidative stress biomarkers linked to cardiovascular disease were associated with frailty and the related outcome of gait speed. We report cross-sectional associations of biomarkers and frailty assessed at Framingham Offspring Study cycle eight. Participants ≥60 years were eligible if they had information on frailty and at least one of the following: C-reactive protein, interleukin-6, tumor necrosis factor receptor 2, 8-epi-FGFα isoprostanes (isoprostanes), lipoprotein phospholipase A2 (LpPLA2) mass or activity, osteoprotegerin, intracellular adhesion molecule-1, monocyte chemoattractant protein-1 or P-selectin. Stepwise logistic models were utilized for frailty and stepwise linear models for gait speed. Covariates included age, sex, body mass index, smoking, and co-morbidities. Odds ratios (ORs) and slope estimates (B) are reported per standard deviation increase of loge-transformed biomarker. Of the 1919 participants, 142 (7 %) were frail. In a stepwise model, frailty odds increased with higher interleukin-6 (OR 1.90, 95 % CI 1.51, 2.38), isoprostanes (OR 1.46, 95 % CI 1.12, 1.92), and LpPLA2 mass (OR 1.29, 95 % CI 1.00, 1.65). Stepwise regression found that slower gait speeds were associated with interleukin-6 (B = −0.025 m/s, 95 % CI 0.04, −0.01), isoprostanes (B = −0.019, 95 % CI −0.03, −0.008), LpPLA2 mass (B = −0.016, 95 % CI −0.03, −0.004), and osteoprotegerin (B = −0.015, 95 % CI −0.03, −0.002, all p |
| تدمد: | 1574-4647 0161-9152 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d75f9fa67f92eab8b4ad7b85937f2d3Test https://doi.org/10.1007/s11357-015-9864-zTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9d75f9fa67f92eab8b4ad7b85937f2d3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15744647 01619152 |
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