دورية أكاديمية
Can urinary biomarkers be used in the outcome assessment of pyeloplasty in children?
| العنوان: | Can urinary biomarkers be used in the outcome assessment of pyeloplasty in children? |
|---|---|
| المؤلفون: | Rupesh Keshri, Krishna Kumar Govindarajan, Medha Rajappa, Kumaravel Sambandan, Bikash Kumar Naredi, Bibekanand Jindal |
| المصدر: | African Journal of Urology, Vol 27, Iss 1, Pp 1-5 (2021) |
| بيانات النشر: | SpringerOpen, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Diseases of the genitourinary system. Urology |
| مصطلحات موضوعية: | Biomarkers, Beta 2-microglobulin, Monocyte Chemotactic Peptide, Transforming growth factor-beta, Pelviureteric junction obstruction, Hydronephrosis, Diseases of the genitourinary system. Urology, RC870-923 |
| الوصف: | Abstract Background To compare the urinary biomarkers—beta 2-microglobulin (β2M), monocyte chemotactic peptide-1 (MCP-1), and transforming growth factor-beta (TGF-β1)—in the outcome assessment of children with pelviureteric junction obstruction (PUJO) undergoing pyeloplasty. Methods A prospective study was conducted on children with PUJO who had pyeloplasty in a tertiary care center from July 2016 to March 2018. Urine samples were obtained from freshly voided urine samples before surgery and after 6 months of pyeloplasty. Ratio between the levels of biomarkers and urinary creatinine before and after surgery were compared. Results A total of 72 patients had pyeloplasty during this period. The mean levels of standardized urinary β2M, MCP-1 and TGF-β1 before surgery were 3.94 ± 4.06, 96.63 ± 117.68 and 310.65 ± 423.87, respectively, which was significantly higher than the corresponding values in the postoperative period, obtained after 6 months of surgery; postoperative mean values were 3.12 ± 3.95, 25.28 ± 32.06, 109.95 ± 118.72 (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1110-5704 1961-9987 |
| العلاقة: | https://doaj.org/toc/1110-5704Test; https://doaj.org/toc/1961-9987Test |
| DOI: | 10.1186/s12301-021-00217-y |
| الوصول الحر: | https://doaj.org/article/fe3f5547356f425e904e059e127d8c39Test |
| رقم الانضمام: | edsdoj.fe3f5547356f425e904e059e127d8c39 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 11105704 19619987 |
|---|---|
| DOI: | 10.1186/s12301-021-00217-y |