دورية أكاديمية
Inhibition of Indoleamine-2,3-dioxygenase (IDO) in Glioblastoma Cells by Oncolytic Herpes Simplex Virus
| العنوان: | Inhibition of Indoleamine-2,3-dioxygenase (IDO) in Glioblastoma Cells by Oncolytic Herpes Simplex Virus |
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| المؤلفون: | Bonnie Reinhart, Lucia Mazzacurati, Adriana Forero, Chang-Sook Hong, Junichi Eguchi, Hideho Okada, Wendy Fellows, Ajay Niranjan, Justus B. Cohen, Joseph C. Glorioso, Paola Grandi |
| المصدر: | Advances in Virology, Vol 2012 (2012) |
| بيانات النشر: | Hindawi Limited, 2012. |
| سنة النشر: | 2012 |
| المجموعة: | LCC:Microbiology |
| مصطلحات موضوعية: | Microbiology, QR1-502 |
| الوصف: | Successful oncolytic virus treatment of malignant glioblastoma multiforme depends on widespread tumor-specific lytic virus replication and escape from mitigating innate immune responses to infection. Here we characterize a new HSV vector, JD0G, that is deleted for ICP0 and the joint sequences separating the unique long and short elements of the viral genome. We observed that JD0G replication was enhanced in certain glioblastoma cell lines compared to HEL cells, suggesting that a vector backbone deleted for ICP0 may be useful for treatment of glioblastoma. The innate immune response to virus infection can potentially impede oncolytic vector replication in human tumors. Indoleamine-2,3-dioxygenase (IDO) is expressed in response to interferon γ (IFNγ) and has been linked to both antiviral functions and to the immune escape of tumor cells. We observed that IFNγ treatment of human glioblastoma cells induced the expression of IDO and that this expression was quelled by infection with both wild-type and JD0G viruses. The role of IDO in inhibiting virus replication and the connection of this protein to the escape of tumor cells from immune surveillance suggest that IDO downregulation by HSV infection may enhance the oncolytic activity of vectors such as JD0G. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1687-8639 1687-8647 |
| العلاقة: | https://doaj.org/toc/1687-8639Test; https://doaj.org/toc/1687-8647Test |
| DOI: | 10.1155/2012/815465 |
| الوصول الحر: | https://doaj.org/article/45761b7156644ee18c3de87d57e7388eTest |
| رقم الانضمام: | edsdoj.45761b7156644ee18c3de87d57e7388e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16878639 16878647 |
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| DOI: | 10.1155/2012/815465 |