Effect of insulin sensitivity on SHBG levels in premenopausal versus postmenopausal obese women
| العنوان: | Effect of insulin sensitivity on SHBG levels in premenopausal versus postmenopausal obese women |
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| المؤلفون: | Fulya Akin, Esma Alkis, Mehmet Bastemir |
| المصدر: | Advances in Therapy. 24:1210-1220 |
| بيانات النشر: | Springer Science and Business Media LLC, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Blood Glucose, obesity, blood pressure measurement, retrospective study, medicine.medical_treatment, insulin blood level, Overweight, thyrotropin, Sex hormone-binding globulin, insulin resistance, Sex Hormone-Binding Globulin, middle aged, polycyclic compounds, Insulin, Pharmacology (medical), Euthyroid, glucose, Gonadal Steroid Hormones, comparative study, pathophysiology, reproductive and urinary physiology, medicine.diagnostic_test, biology, adult, article, euthyroidism, General Medicine, Insulin sensitivity, sex hormone binding globulin, Lipids, Postmenopause, Menopause, aged, female, Postprandial, Sex steroids, medicine.symptom, hormones, hormone substitutes, and hormone antagonists, uric acid blood level, medicine.medical_specialty, premenopause, hormone blood level, sex hormone, Insulin resistance, uric acid, lipid, blood, estradiol, Internal medicine, medicine, cross-sectional study, Humans, controlled study, human, SHBG, Retrospective Studies, business.industry, medicine.disease, major clinical study, clinical feature, glucose blood level, thyrotropin blood level, Cross-Sectional Studies, Endocrinology, estradiol blood level, biology.protein, Lipid profile, business |
| الوصف: | This study was performed to evaluate the impact of insulin sensitivity on sex hormone-binding globulin (SHBG) and sex steroids in premenopausal and postmenopausal euthyroid obese women. A total of 227 women were eligible for this study. All were euthyroid, obese, and overweight; ages ranged from 25 to 69 years. Women were divided into premenopausal (n=151) and postmenopausal (n=76) groups. SHBG, sex steroids, thyrotropin, fasting and postprandial glucose, lipid profile, uric acid, serum insulin, and blood pressure were measured. No significant difference was found in mean SHBG levels between premenopausal and postmenopausal women. The investigators observed that during transition from premenopause to postmenopause, SHBG levels increased in insulin-sensitive women in the postmenopausal group; however, SHBG levels decreased in insulin-resistant women. It was concluded that SHBG blood concentration factors are likely to change during transition from premenopause to postmenopause. The positive effect of estradiol on SHBG levels is probably stronger in premenopausal women than in postmenopausal women. It has been noted that after menopause, the impact of insulin resistance on SHBG level seems more important than the effect of estradiol. ©2007 Health Communications Inc. |
| تدمد: | 1865-8652 0741-238X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c203fcd631131deb34272067bbe599dfTest https://doi.org/10.1007/bf02877767Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....c203fcd631131deb34272067bbe599df |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18658652 0741238X |
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